No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury

BACKGROUND: Opioids effectively reduce chronic pain, but present significant side effects including opioid‐induced constipation. Oxycodone/naloxone decreases pain and constipation in cancer patients, however its effect on spinal cord injury population remains understudied. METHODS: We assessed wheth...

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Autores principales: Sachdeva, Rahul, Hosseinzadeh, Ali, Rizzardo, Aaron, Maharaj, Andrea, Berger, Michael, Krassioukov, Andrei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014000/
https://www.ncbi.nlm.nih.gov/pubmed/36692221
http://dx.doi.org/10.1002/acn3.51734
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author Sachdeva, Rahul
Hosseinzadeh, Ali
Rizzardo, Aaron
Maharaj, Andrea
Berger, Michael
Krassioukov, Andrei
author_facet Sachdeva, Rahul
Hosseinzadeh, Ali
Rizzardo, Aaron
Maharaj, Andrea
Berger, Michael
Krassioukov, Andrei
author_sort Sachdeva, Rahul
collection PubMed
description BACKGROUND: Opioids effectively reduce chronic pain, but present significant side effects including opioid‐induced constipation. Oxycodone/naloxone decreases pain and constipation in cancer patients, however its effect on spinal cord injury population remains understudied. METHODS: We assessed whether oxycodone/naloxone reduces pain, constipation, and severity of autonomic dysreflexia in an individual with spinal cord injury. A 55‐year‐old male with C5 lesion presented with chief complaint of chronic pain received 5/2.5 mg and 20/10 mg oxycodone/naloxone for 6 and 2 weeks, respectively. RESULTS: Oxycodone/naloxone improved pain, bowel function, and autonomic dysreflexia severity. INTERPRETATION: Oxycodone/naloxone was effective in managing chronic pain and constipation in the studied case.
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spelling pubmed-100140002023-03-15 No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury Sachdeva, Rahul Hosseinzadeh, Ali Rizzardo, Aaron Maharaj, Andrea Berger, Michael Krassioukov, Andrei Ann Clin Transl Neurol Case Study BACKGROUND: Opioids effectively reduce chronic pain, but present significant side effects including opioid‐induced constipation. Oxycodone/naloxone decreases pain and constipation in cancer patients, however its effect on spinal cord injury population remains understudied. METHODS: We assessed whether oxycodone/naloxone reduces pain, constipation, and severity of autonomic dysreflexia in an individual with spinal cord injury. A 55‐year‐old male with C5 lesion presented with chief complaint of chronic pain received 5/2.5 mg and 20/10 mg oxycodone/naloxone for 6 and 2 weeks, respectively. RESULTS: Oxycodone/naloxone improved pain, bowel function, and autonomic dysreflexia severity. INTERPRETATION: Oxycodone/naloxone was effective in managing chronic pain and constipation in the studied case. John Wiley and Sons Inc. 2023-01-24 /pmc/articles/PMC10014000/ /pubmed/36692221 http://dx.doi.org/10.1002/acn3.51734 Text en © 2023 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Study
Sachdeva, Rahul
Hosseinzadeh, Ali
Rizzardo, Aaron
Maharaj, Andrea
Berger, Michael
Krassioukov, Andrei
No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury
title No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury
title_full No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury
title_fullStr No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury
title_full_unstemmed No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury
title_short No pain, no strain: Targin® mitigates pain and constipation following spinal cord injury
title_sort no pain, no strain: targin® mitigates pain and constipation following spinal cord injury
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014000/
https://www.ncbi.nlm.nih.gov/pubmed/36692221
http://dx.doi.org/10.1002/acn3.51734
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