Mobile digital gait analysis objectively measures progression in hereditary spastic paraplegia

Progressive spasticity and gait impairment is the functional hallmark of hereditary spastic paraplegia (HSP), but due to inter‐individual variability, longitudinal studies on its progression are scarce. We investigated the progression of gait deficits via mobile digital measurements in conjunction w...

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Detalles Bibliográficos
Autores principales: Loris, Evelyn, Ollenschläger, Malte, Greinwalder, Teresa, Eskofier, Björn, Winkler, Jürgen, Gaßner, Heiko, Regensburger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014001/
https://www.ncbi.nlm.nih.gov/pubmed/36622133
http://dx.doi.org/10.1002/acn3.51725
Descripción
Sumario:Progressive spasticity and gait impairment is the functional hallmark of hereditary spastic paraplegia (HSP), but due to inter‐individual variability, longitudinal studies on its progression are scarce. We investigated the progression of gait deficits via mobile digital measurements in conjunction with clinical and patient‐reported outcome parameters. Our cohort included adult HSP patients (n = 55) with up to 77 months of follow‐up. Gait speed showed a significant association with SPRS progression. Changes in stride time and gait variability correlated to fear of falling and quality of life, providing evidence that gait parameters are meaningful measures of HSP progression.

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