Cargando…

Verifying in vitro‐determined enzyme contributions to cannabidiol clearance for exposure predictions in human through physiologically‐based pharmacokinetic modeling

Cannabidiol (CBD) is approved for treatment of seizures associated with two forms of epilepsy that become apparent in infancy or early childhood. To consider an adult physiologically‐based pharmacokinetic (PBPK) model for pediatric scaling, we assessed in vitro‐derived cytochrome P450 (CYP) and urid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yeung, Cindy H. T., Beers, Jessica L., Jackson, Klarissa D., Edginton, Andrea N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014054/ https://www.ncbi.nlm.nih.gov/pubmed/36540909 http://dx.doi.org/10.1002/psp4.12908

Ejemplares similares

Quantifying breast milk intake by term and preterm infants for input into paediatric physiologically based pharmacokinetic models
por: Yeung, Cindy H.T., et al.
Publicado: (2020)

Cytosolic Enzymes Generate Cannabinoid Metabolites 7-Carboxycannabidiol and 11-Nor-9-carboxytetrahydrocannabinol
por: Beers, Jessica L., et al.
Publicado: (2023)

Physiologically‐Based Pharmacokinetic Modeling vs. Allometric Scaling for the Prediction of Infliximab Pharmacokinetics in Pediatric Patients
por: Malik, Paul R. V., et al.
Publicado: (2019)

Using Physiologically Based Pharmacokinetic Modeling for Mechanistic Insight: Cases of Reverse Translation
por: Edginton, Andrea N.
Publicado: (2017)

Physiologically Based Pharmacokinetic Modeling and Simulation in Pediatric Drug Development
por: Maharaj, A R, et al.
Publicado: (2014)

Cannabidiol and Cannabidiol Metabolites: Pharmacokinetics, Interaction with Food, and Influence on Liver Function
por: Abbotts, Kieran Shay Struebin, et al.
Publicado: (2022)

Current Scientific Considerations to Verify Physiologically‐Based Pharmacokinetic Models and Their Implications for Locally Acting Products
por: Zhao, Liang, et al.
Publicado: (2019)

Addressing maternal medication use during breastfeeding using clinical resources and a novel physiologically based pharmacokinetic model-derived metric: A qualitative study
por: Yeung, Cindy Hoi Ting, et al.
Publicado: (2023)

Plasma Pharmacokinetics of Cannabidiol Following Oral Administration of Cannabidiol Oil to Dairy Calves
por: Meyer, Kelsey, et al.
Publicado: (2022)

Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO
por: Watt, Kevin M., et al.
Publicado: (2018)

Physiologically Based Pharmacokinetic Modelling for Nicotine and Cotinine Clearance in Pregnant Women
por: Amice, Basile, et al.
Publicado: (2021)

A Systematic Review on the Pharmacokinetics of Cannabidiol in Humans
por: Millar, Sophie A., et al.
Publicado: (2018)

The Influence of Cannabidiol on the Pharmacokinetics of Methylphenidate in Healthy Subjects
por: Markowitz, John S., et al.
Publicado: (2022)

Population physiologically-based pharmacokinetic model incorporating lymphatic uptake for a subcutaneously administered pegylated peptide
por: Offman, Elliot, et al.
Publicado: (2016)

Pharmacokinetics of escalating single‐dose administration of cannabidiol to cats
por: Rozental, Aaron J., et al.
Publicado: (2022)

Integration of Placental Transfer in a Fetal–Maternal Physiologically Based Pharmacokinetic Model to Characterize Acetaminophen Exposure and Metabolic Clearance in the Fetus
por: Mian, Paola, et al.
Publicado: (2020)

Characterizing Pharmacokinetics in Children With Obesity—Physiological, Drug, Patient, and Methodological Considerations
por: Gerhart, Jacqueline G., et al.
Publicado: (2022)

Measured GFR by Utilizing Population Pharmacokinetic Methods to Determine Iohexol Clearance
por: Åsberg, Anders, et al.
Publicado: (2019)

A Retrospective Evaluation of Allometry, Population Pharmacokinetics, and Physiologically‐Based Pharmacokinetics for Pediatric Dosing Using Clearance as a Surrogate
por: Wu, Qier, et al.
Publicado: (2019)

Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs
por: Gamble, Lauri-Jo, et al.
Publicado: (2018)

Pharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge
por: Di Salvo, Alessandra, et al.
Publicado: (2023)

Role of Cytochrome P450 Enzymes in the Metabolic Activation of Tyrosine Kinase Inhibitors
por: Jackson, Klarissa D., et al.
Publicado: (2018)

The Physiology of Insulin Clearance
por: Bergman, Richard N., et al.
Publicado: (2022)

Predicting Hydroxychloroquine Clearance in Healthy and Diseased Populations Using a Physiologically Based Pharmacokinetic Approach
por: Alqahtani, Faleh, et al.
Publicado: (2023)

Development of an Adult Physiologically Based Pharmacokinetic Model of Solithromycin in Plasma and Epithelial Lining Fluid
por: Salerno, Sara N., et al.
Publicado: (2017)

Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions
por: Anderson, Lyndsey L., et al.
Publicado: (2019)

Pharmacokinetics of Cannabidiol Following Intranasal, Intrarectal, and Oral Administration in Healthy Dogs
por: Polidoro, Dakir, et al.
Publicado: (2022)

Sex Differences in the Neuropsychiatric Effects and Pharmacokinetics of Cannabidiol: A Scoping Review
por: Matheson, Justin, et al.
Publicado: (2022)

Pharmacokinetics of cannabidiol following single oral and oral transmucosal administration in dogs
por: della Rocca, Giorgia, et al.
Publicado: (2023)

Pharmacokinetic modelling of orally administered cannabidiol and implications for medication control in horses
por: Eichler, Fabienne, et al.
Publicado: (2023)

Novel Approaches to Characterize Individual Drug Metabolism and Advance Precision Medicine
por: Jackson, Klarissa D., et al.
Publicado: (2023)

Biodistribution and Physiologically-Based Pharmacokinetic Modeling of Gold Nanoparticles in Mice with Interspecies Extrapolation
por: Aborig, Mohamed, et al.
Publicado: (2019)

A Physiologically Based Pharmacokinetic Model to Predict Determinants of Variability in Epirubicin Exposure and Tissue Distribution
por: Ansaar, Radwan, et al.
Publicado: (2023)

The contribution of apixaban renal clearance to total clearance
por: Frost, Charles, et al.
Publicado: (2015)

1396. Predictions of Isavuconazonium Sulfate Dosage in Patients Aged 6 Months: <18 Years by Physiologically Based Pharmacokinetic Modeling
por: Desai, Amit, et al.
Publicado: (2018)

Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid
por: Merrick, John, et al.
Publicado: (2016)

Inadequate Regulation Contributes to Mislabeled Online Cannabidiol Products
por: Freedman, Daniel A., et al.
Publicado: (2018)

Keypunching and verifying
por: Farina, Mario V.
Publicado: (1973)

To trust? Or to verify?
por: Harendza, Sigrid
Publicado: (2018)

Verifiable biology
por: Konur, Savas, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_v0nj12cm87mmlaf15o94b5n72l