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A “middle‐out approach” for the prediction of human drug disposition from preclinical data using simplified physiologically based pharmacokinetic (PBPK) models

Simplified physiologically based pharmacokinetic (PBPK) models using estimated tissue‐to‐unbound plasma partition coefficients (Kpus) were previously investigated by fitting them to in vivo pharmacokinetic (PK) data. After optimization with preclinical data, the performance of these models for extra...

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Detalles Bibliográficos
Autores principales:	Yau, Estelle, Gertz, Michael, Ogungbenro, Kayode, Aarons, Leon, Olivares‐Morales, Andrés
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014056/ https://www.ncbi.nlm.nih.gov/pubmed/36647756 http://dx.doi.org/10.1002/psp4.12915

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