Cargando…
Endosomal trafficking protein TBC‐2 modulates stress resistance and lifespan through DAF‐16‐dependent and independent mechanisms
The FOXO transcription factor, DAF‐16, plays an integral role in insulin/IGF‐1 signaling (IIS) and stress response. In conditions of stress or decreased IIS, DAF‐16 moves to the nucleus where it activates genes that promote survival. To gain insight into the role of endosomal trafficking in resistan...
Autores principales: | Traa, Annika, Soo, Sonja K., AlOkda, Abdelrahman, Ko, Bokang, Rocheleau, Christian E., Van Raamsdonk, Jeremy M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014066/ https://www.ncbi.nlm.nih.gov/pubmed/36794357 http://dx.doi.org/10.1111/acel.13762 |
Ejemplares similares
-
Endosomal trafficking protein TBC-2 is required for the longevity of long-lived mitochondrial mutants
por: Traa, Annika, et al.
Publicado: (2023) -
The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan
por: Meraş, İçten, et al.
Publicado: (2022) -
Effect of DMSO on lifespan and physiology in
C. elegans
: Implications for use of DMSO as a solvent for compound delivery
por: AlOkda, Abdelrahman, et al.
Publicado: (2022) -
Mitochondrial thioredoxin system is required for enhanced stress resistance and extended longevity in long-lived mitochondrial mutants
por: Harris-Gauthier, Namastheé, et al.
Publicado: (2022) -
Evolutionarily Conserved Role of Thioredoxin Systems in Determining Longevity
por: AlOkda, Abdelrahman, et al.
Publicado: (2023)