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Proof‐of‐concept for incorporating mechanistic insights from multi‐omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae

Carbapenemase‐resistant Klebsiella pneumoniae (KP) resistant to multiple antibiotic classes necessitates optimized combination therapy. Our objective is to build a workflow leveraging omics and bacterial count data to identify antibiotic mechanisms that can be used to design and optimize combination...

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Detalles Bibliográficos
Autores principales:	Hanafin, Patrick O., Abdul Rahim, Nusaibah, Sharma, Rajnikant, Cess, Colin G., Finley, Stacey D., Bergen, Phillip J., Velkov, Tony, Li, Jian, Rao, Gauri G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014067/ https://www.ncbi.nlm.nih.gov/pubmed/36661181 http://dx.doi.org/10.1002/psp4.12923

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