Targeting pleckstrin-2/Akt signaling reduces proliferation in myeloproliferative neoplasm models

Myeloproliferative neoplasms (MPNs) are characterized by the activated JAK2/STAT pathway. Pleckstrin-2 (Plek2) is a downstream target of the JAK2/STAT5 pathway and is overexpressed in patients with MPNs. We previously revealed that Plek2 plays critical roles in the pathogenesis of JAK2-mutated MPNs....

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Detalles Bibliográficos
Autores principales: Han, Xu, Mei, Yang, Mishra, Rama K., Bi, Honghao, Jain, Atul D., Schiltz, Gary E., Zhao, Baobing, Sukhanova, Madina, Wang, Pan, Grigorescu, Arabela A., Weber, Patricia C., Piwinski, John J., Prado, Miguel A., Paulo, Joao A., Stephens, Len, Anderson, Karen E., Abrams, Charles S., Yang, Jing, Ji, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014099/
https://www.ncbi.nlm.nih.gov/pubmed/36719747
http://dx.doi.org/10.1172/JCI159638

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