The immunometabolite itaconate stimulates OXGR1 to promote mucociliary clearance during the pulmonary innate immune response

Pathogens and inflammatory conditions rapidly induce the expression of immune-responsive gene 1 (IRG1) in cells of myeloid lineage. IRG1 encodes an aconitate decarboxylase (ACOD1) that produces the immunomodulatory metabolite itaconate (ITA). In addition to rapid intracellular accumulation, ITA is a...

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Detalles Bibliográficos
Autores principales: Zeng, Yi-Rong, Song, Jun-Bin, Wang, Dezheng, Huang, Zi-Xuan, Zhang, Cheng, Sun, Yi-Ping, Shu, Gang, Xiong, Yue, Guan, Kun-Liang, Ye, Dan, Wang, Pu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014103/
https://www.ncbi.nlm.nih.gov/pubmed/36919698
http://dx.doi.org/10.1172/JCI160463

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