Preclinical and clinical evidence for suppression of alcohol intake by apremilast

Treatment options for alcohol use disorders (AUDs) have minimally advanced since 2004, while the annual deaths and economic toll have increased alarmingly. Phosphodiesterase type 4 (PDE4) is associated with alcohol and nicotine dependence. PDE4 inhibitors were identified as a potential AUD treatment...

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Detalles Bibliográficos
Autores principales: Grigsby, Kolter B., Mangieri, Regina A., Roberts, Amanda J., Lopez, Marcelo F., Firsick, Evan J., Townsley, Kayla G., Beneze, Alan, Bess, Jessica, Eisenstein, Toby K., Meissler, Joseph J., Light, John M., Miller, Jenny, Quello, Susan, Shadan, Farhad, Skinner, Michael, Aziz, Heather C., Metten, Pamela, Morrisett, Richard A., Crabbe, John C., Roberto, Marisa, Becker, Howard C., Mason, Barbara J., Ozburn, Angela R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014105/
https://www.ncbi.nlm.nih.gov/pubmed/36656645
http://dx.doi.org/10.1172/JCI159103

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