Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations

Mutations in the human progranulin (GRN) gene are a leading cause of frontotemporal lobar degeneration (FTLD). While previous studies implicate aberrant microglial activation as a disease-driving factor in neurodegeneration in the thalamocortical circuit in Grn(–/–) mice, the exact mechanism for neu...

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Detalles Bibliográficos
Autores principales: Marsan, Elise, Velmeshev, Dmitry, Ramsey, Arren, Patel, Ravi K., Zhang, Jiasheng, Koontz, Mark, Andrews, Madeline G., de Majo, Martina, Mora, Cristina, Blumenfeld, Jessica, Li, Alissa N., Spina, Salvatore, Grinberg, Lea T., Seeley, William W., Miller, Bruce L., Ullian, Erik M., Krummel, Matthew F., Kriegstein, Arnold R., Huang, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014110/
https://www.ncbi.nlm.nih.gov/pubmed/36602862
http://dx.doi.org/10.1172/JCI164919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014110/
https://www.ncbi.nlm.nih.gov/pubmed/36602862
http://dx.doi.org/10.1172/JCI164919

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