Clonally expanded HIV-1 proviruses with 5′-leader defects can give rise to nonsuppressible residual viremia

BACKGROUND: Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below the detection limit of clinical assays. However, some individuals experience persistent nonsuppressible viremia (NSV) originating from CD4(+) T cell clones carrying infectious proviruses. Defective provirus...

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Detalles Bibliográficos
Autores principales: White, Jennifer A., Wu, Fengting, Yasin, Saif, Moskovljevic, Milica, Varriale, Joseph, Dragoni, Filippo, Camilo-Contreras, Angelica, Duan, Jiayi, Zheng, Mei Y., Tadzong, Ndeh F., Patel, Heer B., Quiambao, Jeanelle Mae C., Rhodehouse, Kyle, Zhang, Hao, Lai, Jun, Beg, Subul A., Delannoy, Michael, Kilcrease, Christin, Hoffmann, Christopher J., Poulin, Sébastien, Chano, Frédéric, Tremblay, Cécile, Cherian, Jerald, Barditch-Crovo, Patricia, Chida, Natasha, Moore, Richard D., Summers, Michael F., Siliciano, Robert F., Siliciano, Janet D., Simonetti, Francesco R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Clinical Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014112/
https://www.ncbi.nlm.nih.gov/pubmed/36602866
http://dx.doi.org/10.1172/JCI165245

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