HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation

High mobility group A1 (HMGA1) chromatin regulators are upregulated in diverse tumors where they portend adverse outcomes, although how they function in cancer remains unclear. Pancreatic ductal adenocarcinomas (PDACs) are highly lethal tumors characterized by dense desmoplastic stroma composed pred...

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Detalles Bibliográficos
Autores principales: Chia, Lionel, Wang, Bowen, Kim, Jung-Hyun, Luo, Li Z., Shuai, Shuai, Herrera, Iliana, Chen, Sophia Y., Li, Liping, Xian, Lingling, Huso, Tait, Heydarian, Mohammad, Reddy, Karen, Sung, Woo Jung, Ishiyama, Shun, Guo, Gongbo, Jaffee, Elizabeth, Zheng, Lei, Cope, Leslie M., Gabrielson, Kathy, Wood, Laura, Resar, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014113/
https://www.ncbi.nlm.nih.gov/pubmed/36919699
http://dx.doi.org/10.1172/JCI151601

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