MFN1 augmentation prevents retinal degeneration in a Charcot-Marie-Tooth type 2A mouse model

Charcot-Marie-Tooth disease type 2A (CMT2A), the most common inherited peripheral axonal neuropathy, is associated with more than 100 dominant mutations, including R94Q as the most abundant mutation in the Mitofusin2 (MFN2) gene. CMT2A is characterized by progressive motor and sensory loss, color-vi...

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Detalles Bibliográficos
Autores principales: Shahin, Saba, Lu, Bin, Zhou, Yueqin, Xu, Hui, Chetsawang, Jason, Baloh, Robert H., Wang, Shaomei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014277/
https://www.ncbi.nlm.nih.gov/pubmed/36936780
http://dx.doi.org/10.1016/j.isci.2023.106270

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