Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation

Transient receptor potential canonical type 6 (TRPC6) is a non-voltage-gated channel that principally conducts calcium. Elevated channel activation contributes to fibrosis, hypertrophy, and proteinuria, often coupled to stimulation of nuclear factor of activated T-cells (NFAT). TRPC6 is post-transla...

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Detalles Bibliográficos
Autores principales: Mishra, Sumita, Ma, Junfeng, McKoy, Desirae, Sasaki, Masayuki, Farinelli, Federica, Page, Richard C., Ranek, Mark J., Zachara, Natasha, Kass, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014292/
https://www.ncbi.nlm.nih.gov/pubmed/36936781
http://dx.doi.org/10.1016/j.isci.2023.106294

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