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Abnormally primed CD8 T cells: The Achilles’ heel of CHB

Chronic hepatitis B virus (HBV) infection continues to be a significant public health challenge, and more than 250 million people around world are infected with HBV. The clearance of HBV with virus-specific CD8 T cells is critical for a functional cure. However, naïve HBV-specific CD8 T cells are he...

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Autores principales: Chen, Xiaoqing, Liu, Xue, Jiang, Yichao, Xia, Ningshao, Liu, Chao, Luo, Wenxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014547/
https://www.ncbi.nlm.nih.gov/pubmed/36936922
http://dx.doi.org/10.3389/fimmu.2023.1106700
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author Chen, Xiaoqing
Liu, Xue
Jiang, Yichao
Xia, Ningshao
Liu, Chao
Luo, Wenxin
author_facet Chen, Xiaoqing
Liu, Xue
Jiang, Yichao
Xia, Ningshao
Liu, Chao
Luo, Wenxin
author_sort Chen, Xiaoqing
collection PubMed
description Chronic hepatitis B virus (HBV) infection continues to be a significant public health challenge, and more than 250 million people around world are infected with HBV. The clearance of HBV with virus-specific CD8 T cells is critical for a functional cure. However, naïve HBV-specific CD8 T cells are heavily hindered during the priming process, and this phenomenon is closely related to abnormal cell and signal interactions in the complex immune microenvironment. Here, we briefly summarize the recent progress in understanding the abnormal priming of HBV-specific CD8 T cells and some corresponding immunotherapies to facilitate their functional recovery, which provides a novel perspective for the design and development of immunotherapy for chronic HBV infection (CHB). Finally, we also highlight the balance between viral clearance and pathological liver injury induced by CD8 T-cell activation that should be carefully considered during drug development.
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spelling pubmed-100145472023-03-16 Abnormally primed CD8 T cells: The Achilles’ heel of CHB Chen, Xiaoqing Liu, Xue Jiang, Yichao Xia, Ningshao Liu, Chao Luo, Wenxin Front Immunol Immunology Chronic hepatitis B virus (HBV) infection continues to be a significant public health challenge, and more than 250 million people around world are infected with HBV. The clearance of HBV with virus-specific CD8 T cells is critical for a functional cure. However, naïve HBV-specific CD8 T cells are heavily hindered during the priming process, and this phenomenon is closely related to abnormal cell and signal interactions in the complex immune microenvironment. Here, we briefly summarize the recent progress in understanding the abnormal priming of HBV-specific CD8 T cells and some corresponding immunotherapies to facilitate their functional recovery, which provides a novel perspective for the design and development of immunotherapy for chronic HBV infection (CHB). Finally, we also highlight the balance between viral clearance and pathological liver injury induced by CD8 T-cell activation that should be carefully considered during drug development. Frontiers Media S.A. 2023-03-01 /pmc/articles/PMC10014547/ /pubmed/36936922 http://dx.doi.org/10.3389/fimmu.2023.1106700 Text en Copyright © 2023 Chen, Liu, Jiang, Xia, Liu and Luo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Xiaoqing
Liu, Xue
Jiang, Yichao
Xia, Ningshao
Liu, Chao
Luo, Wenxin
Abnormally primed CD8 T cells: The Achilles’ heel of CHB
title Abnormally primed CD8 T cells: The Achilles’ heel of CHB
title_full Abnormally primed CD8 T cells: The Achilles’ heel of CHB
title_fullStr Abnormally primed CD8 T cells: The Achilles’ heel of CHB
title_full_unstemmed Abnormally primed CD8 T cells: The Achilles’ heel of CHB
title_short Abnormally primed CD8 T cells: The Achilles’ heel of CHB
title_sort abnormally primed cd8 t cells: the achilles’ heel of chb
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014547/
https://www.ncbi.nlm.nih.gov/pubmed/36936922
http://dx.doi.org/10.3389/fimmu.2023.1106700
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