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IgA-producing B cells in lung homeostasis and disease
Immunoglobulin A (IgA) is the most abundant Ig in mucosae where it plays key roles in host defense against pathogens and in mucosal immunoregulation. Whereas intense research has established the different roles of secretory IgA in the gut, its function has been much less studied in the lung. This re...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014553/ https://www.ncbi.nlm.nih.gov/pubmed/36936934 http://dx.doi.org/10.3389/fimmu.2023.1117749 |
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author | Bertrand, Youri Sánchez-Montalvo, Alba Hox, Valérie Froidure, Antoine Pilette, Charles |
author_facet | Bertrand, Youri Sánchez-Montalvo, Alba Hox, Valérie Froidure, Antoine Pilette, Charles |
author_sort | Bertrand, Youri |
collection | PubMed |
description | Immunoglobulin A (IgA) is the most abundant Ig in mucosae where it plays key roles in host defense against pathogens and in mucosal immunoregulation. Whereas intense research has established the different roles of secretory IgA in the gut, its function has been much less studied in the lung. This review will first summarize the state-of-the-art knowledge on the distribution and phenotype of IgA(+) B cells in the human lung in both homeostasis and disease. Second, it will analyze the studies looking at cellular and molecular mechanisms of homing and priming of IgA(+) B cells in the lung, notably following immunization. Lastly, published data on observations related to IgA and IgA(+) B cells in lung and airway disease such as asthma, cystic fibrosis, idiopathic pulmonary fibrosis, or chronic rhinosinusitis, will be discussed. Collectively it provides the state-of-the-art of our current understanding of the biology of IgA-producing cells in the airways and identifies gaps that future research should address in order to improve mucosal protection against lung infections and chronic inflammatory diseases. |
format | Online Article Text |
id | pubmed-10014553 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100145532023-03-16 IgA-producing B cells in lung homeostasis and disease Bertrand, Youri Sánchez-Montalvo, Alba Hox, Valérie Froidure, Antoine Pilette, Charles Front Immunol Immunology Immunoglobulin A (IgA) is the most abundant Ig in mucosae where it plays key roles in host defense against pathogens and in mucosal immunoregulation. Whereas intense research has established the different roles of secretory IgA in the gut, its function has been much less studied in the lung. This review will first summarize the state-of-the-art knowledge on the distribution and phenotype of IgA(+) B cells in the human lung in both homeostasis and disease. Second, it will analyze the studies looking at cellular and molecular mechanisms of homing and priming of IgA(+) B cells in the lung, notably following immunization. Lastly, published data on observations related to IgA and IgA(+) B cells in lung and airway disease such as asthma, cystic fibrosis, idiopathic pulmonary fibrosis, or chronic rhinosinusitis, will be discussed. Collectively it provides the state-of-the-art of our current understanding of the biology of IgA-producing cells in the airways and identifies gaps that future research should address in order to improve mucosal protection against lung infections and chronic inflammatory diseases. Frontiers Media S.A. 2023-03-01 /pmc/articles/PMC10014553/ /pubmed/36936934 http://dx.doi.org/10.3389/fimmu.2023.1117749 Text en Copyright © 2023 Bertrand, Sánchez-Montalvo, Hox, Froidure and Pilette https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Bertrand, Youri Sánchez-Montalvo, Alba Hox, Valérie Froidure, Antoine Pilette, Charles IgA-producing B cells in lung homeostasis and disease |
title | IgA-producing B cells in lung homeostasis and disease |
title_full | IgA-producing B cells in lung homeostasis and disease |
title_fullStr | IgA-producing B cells in lung homeostasis and disease |
title_full_unstemmed | IgA-producing B cells in lung homeostasis and disease |
title_short | IgA-producing B cells in lung homeostasis and disease |
title_sort | iga-producing b cells in lung homeostasis and disease |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014553/ https://www.ncbi.nlm.nih.gov/pubmed/36936934 http://dx.doi.org/10.3389/fimmu.2023.1117749 |
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