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Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway

Gastric cancer (GC) is a prevalent malignant neoplasm that poses a serious threat to human health. Overexpression of Aurora A (AURKA) is frequently associated with the self-renewal and tumorigenicity of various cancers. Chebulagic acid (CA) has been examined as a potential tumor suppressor based on...

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Autores principales: Zhao, Jing, Shi, Yunfu, Ma, Yubo, Pan, Libin, Wang, Yanan, Yuan, Li, Dong, Jinyun, Ying, Jieer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014572/
https://www.ncbi.nlm.nih.gov/pubmed/36937887
http://dx.doi.org/10.3389/fphar.2023.1143427
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author Zhao, Jing
Shi, Yunfu
Ma, Yubo
Pan, Libin
Wang, Yanan
Yuan, Li
Dong, Jinyun
Ying, Jieer
author_facet Zhao, Jing
Shi, Yunfu
Ma, Yubo
Pan, Libin
Wang, Yanan
Yuan, Li
Dong, Jinyun
Ying, Jieer
author_sort Zhao, Jing
collection PubMed
description Gastric cancer (GC) is a prevalent malignant neoplasm that poses a serious threat to human health. Overexpression of Aurora A (AURKA) is frequently associated with the self-renewal and tumorigenicity of various cancers. Chebulagic acid (CA) has been examined as a potential tumor suppressor based on its ability against numerous tumor biological activities. However, the possible mechanisms of CA inhibition of the progression of GC by mediating the AURKA/β-catenin/Wnt signaling pathway have not been investigated. The present study investigated the level of AURKA expression in GC. We further examined the effect of CA on cell proliferation, migration, and apoptosis in the MKN1 and NUGC3 GC cell lines, and its efficacy in suppressing tumor growth was assessed in tumor bearing mice model. We demonstrated that AURKA was highly expressed in GC and associated with poor prognosis. We demonstrated that treatment with CA significantly inhibited the proliferation and migration of GC cells and induced apoptosis. Compared to the vehicle group, CA treatment severely diminished the volume and weight and the metastasis of tumors. CA also inhibited the expression of AURKA and the AURKA/β-catenin/Wnt signaling pathway in vitro and in vivo. Collectively, the present results demonstrated that high expression of AURKA may be an independent factor of poor prognosis in patients with GC, and CA significantly suppressed the tumor biological functions of GC and inhibited the AURKA/β-catenin/Wnt pathway.
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spelling pubmed-100145722023-03-16 Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway Zhao, Jing Shi, Yunfu Ma, Yubo Pan, Libin Wang, Yanan Yuan, Li Dong, Jinyun Ying, Jieer Front Pharmacol Pharmacology Gastric cancer (GC) is a prevalent malignant neoplasm that poses a serious threat to human health. Overexpression of Aurora A (AURKA) is frequently associated with the self-renewal and tumorigenicity of various cancers. Chebulagic acid (CA) has been examined as a potential tumor suppressor based on its ability against numerous tumor biological activities. However, the possible mechanisms of CA inhibition of the progression of GC by mediating the AURKA/β-catenin/Wnt signaling pathway have not been investigated. The present study investigated the level of AURKA expression in GC. We further examined the effect of CA on cell proliferation, migration, and apoptosis in the MKN1 and NUGC3 GC cell lines, and its efficacy in suppressing tumor growth was assessed in tumor bearing mice model. We demonstrated that AURKA was highly expressed in GC and associated with poor prognosis. We demonstrated that treatment with CA significantly inhibited the proliferation and migration of GC cells and induced apoptosis. Compared to the vehicle group, CA treatment severely diminished the volume and weight and the metastasis of tumors. CA also inhibited the expression of AURKA and the AURKA/β-catenin/Wnt signaling pathway in vitro and in vivo. Collectively, the present results demonstrated that high expression of AURKA may be an independent factor of poor prognosis in patients with GC, and CA significantly suppressed the tumor biological functions of GC and inhibited the AURKA/β-catenin/Wnt pathway. Frontiers Media S.A. 2023-03-01 /pmc/articles/PMC10014572/ /pubmed/36937887 http://dx.doi.org/10.3389/fphar.2023.1143427 Text en Copyright © 2023 Zhao, Shi, Ma, Pan, Wang, Yuan, Dong and Ying. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Zhao, Jing
Shi, Yunfu
Ma, Yubo
Pan, Libin
Wang, Yanan
Yuan, Li
Dong, Jinyun
Ying, Jieer
Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway
title Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway
title_full Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway
title_fullStr Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway
title_full_unstemmed Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway
title_short Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway
title_sort chebulagic acid suppresses gastric cancer by inhibiting the aurka/β-catenin/wnt pathway
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014572/
https://www.ncbi.nlm.nih.gov/pubmed/36937887
http://dx.doi.org/10.3389/fphar.2023.1143427
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