STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes

Stimulator of interferon genes (STING) is essential for the type I interferon response against a variety of DNA pathogens. Upon emergence of cytosolic DNA, STING translocates from the endoplasmic reticulum to the Golgi where STING activates the downstream kinase TBK1, then to lysosome through recycl...

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Detalles Bibliográficos
Autores principales: Kuchitsu, Yoshihiko, Mukai, Kojiro, Uematsu, Rei, Takaada, Yuki, Shinojima, Ayumi, Shindo, Ruri, Shoji, Tsumugi, Hamano, Shiori, Ogawa, Emari, Sato, Ryota, Miyake, Kensuke, Kato, Akihisa, Kawaguchi, Yasushi, Nishitani-Isa, Masahiko, Izawa, Kazushi, Nishikomori, Ryuta, Yasumi, Takahiro, Suzuki, Takehiro, Dohmae, Naoshi, Uemura, Takefumi, Barber, Glen N., Arai, Hiroyuki, Waguri, Satoshi, Taguchi, Tomohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014584/
https://www.ncbi.nlm.nih.gov/pubmed/36918692
http://dx.doi.org/10.1038/s41556-023-01098-9

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