A neurodevelopmental epigenetic programme mediated by SMARCD3–DAB1–Reelin signalling is hijacked to promote medulloblastoma metastasis

How abnormal neurodevelopment relates to the tumour aggressiveness of medulloblastoma (MB), the most common type of embryonal tumour, remains elusive. Here we uncover a neurodevelopmental epigenomic programme that is hijacked to induce MB metastatic dissemination. Unsupervised analyses of integrated...

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Detalles Bibliográficos
Autores principales: Zou, Han, Poore, Bradley, Brown, Emily E., Qian, Jieqi, Xie, Bin, Asimakidou, Evridiki, Razskazovskiy, Vladislav, Ayrapetian, Deanna, Sharma, Vaibhav, Xia, Shunjin, Liu, Fei, Chen, Apeng, Guan, Yongchang, Li, Zhengwei, Wanggou, Siyi, Saulnier, Olivier, Ly, Michelle, Fellows-Mayle, Wendy, Xi, Guifa, Tomita, Tadanori, Resnick, Adam C., Mack, Stephen C., Raabe, Eric H., Eberhart, Charles G., Sun, Dandan, Stronach, Beth E., Agnihotri, Sameer, Kohanbash, Gary, Lu, Songjian, Herrup, Karl, Rich, Jeremy N., Gittes, George K., Broniscer, Alberto, Hu, Zhongliang, Li, Xuejun, Pollack, Ian F., Friedlander, Robert M., Hainer, Sarah J., Taylor, Michael D., Hu, Baoli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014585/
https://www.ncbi.nlm.nih.gov/pubmed/36849558
http://dx.doi.org/10.1038/s41556-023-01093-0

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