Evaluation of levocetirizine in beagle dog and cynomolgus monkey telemetry assays: Defining the no QTc effect profile by timepoint and concentration‐QTc analysis

In prior clinical studies, levocetirizine (LEVO) has demonstrated no effect on ventricular repolarization (QTc intervals), therefore it is a relevant negative control to assess in nonclinical assays to define low proarrhythmic risk. LEVO was tested in beagle dog and cynomolgus monkey (nonhuman prima...

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Detalles Bibliográficos
Autores principales: Engwall, Michael J., Baublits, Joel, Chandra, Fiona A., Jones, Zack W., Wahlstrom, Jan, Chui, Ray W., Vargas, Hugo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014691/
https://www.ncbi.nlm.nih.gov/pubmed/36369797
http://dx.doi.org/10.1111/cts.13454

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