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Regulation of microglia function by neural stem cells

Neural stem and precursor cells (NPCs) build and regenerate the central nervous system (CNS) by maintaining their pool (self-renewal) and differentiating into neurons, astrocytes, and oligodendrocytes (multipotency) throughout life. This has inspired research into pro-regenerative therapies that uti...

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Autores principales: de Almeida, Monique M. A., Goodkey, Kara, Voronova, Anastassia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014810/
https://www.ncbi.nlm.nih.gov/pubmed/36937181
http://dx.doi.org/10.3389/fncel.2023.1130205
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author de Almeida, Monique M. A.
Goodkey, Kara
Voronova, Anastassia
author_facet de Almeida, Monique M. A.
Goodkey, Kara
Voronova, Anastassia
author_sort de Almeida, Monique M. A.
collection PubMed
description Neural stem and precursor cells (NPCs) build and regenerate the central nervous system (CNS) by maintaining their pool (self-renewal) and differentiating into neurons, astrocytes, and oligodendrocytes (multipotency) throughout life. This has inspired research into pro-regenerative therapies that utilize transplantation of exogenous NPCs or recruitment of endogenous adult NPCs for CNS regeneration and repair. Recent advances in single-cell RNA sequencing and other “omics” have revealed that NPCs express not just traditional progenitor-related genes, but also genes involved in immune function. Here, we review how NPCs exert immunomodulatory function by regulating the biology of microglia, immune cells that are present in NPC niches and throughout the CNS. We discuss the role of transplanted and endogenous NPCs in regulating microglia fates, such as survival, proliferation, migration, phagocytosis and activation, in the developing, injured and degenerating CNS. We also provide a literature review on NPC-specific mediators that are responsible for modulating microglia biology. Our review highlights the immunomodulatory properties of NPCs and the significance of these findings in the context of designing pro-regenerative therapies for degenerating and diseased CNS.
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spelling pubmed-100148102023-03-16 Regulation of microglia function by neural stem cells de Almeida, Monique M. A. Goodkey, Kara Voronova, Anastassia Front Cell Neurosci Neuroscience Neural stem and precursor cells (NPCs) build and regenerate the central nervous system (CNS) by maintaining their pool (self-renewal) and differentiating into neurons, astrocytes, and oligodendrocytes (multipotency) throughout life. This has inspired research into pro-regenerative therapies that utilize transplantation of exogenous NPCs or recruitment of endogenous adult NPCs for CNS regeneration and repair. Recent advances in single-cell RNA sequencing and other “omics” have revealed that NPCs express not just traditional progenitor-related genes, but also genes involved in immune function. Here, we review how NPCs exert immunomodulatory function by regulating the biology of microglia, immune cells that are present in NPC niches and throughout the CNS. We discuss the role of transplanted and endogenous NPCs in regulating microglia fates, such as survival, proliferation, migration, phagocytosis and activation, in the developing, injured and degenerating CNS. We also provide a literature review on NPC-specific mediators that are responsible for modulating microglia biology. Our review highlights the immunomodulatory properties of NPCs and the significance of these findings in the context of designing pro-regenerative therapies for degenerating and diseased CNS. Frontiers Media S.A. 2023-03-01 /pmc/articles/PMC10014810/ /pubmed/36937181 http://dx.doi.org/10.3389/fncel.2023.1130205 Text en Copyright © 2023 de Almeida, Goodkey and Voronova. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
de Almeida, Monique M. A.
Goodkey, Kara
Voronova, Anastassia
Regulation of microglia function by neural stem cells
title Regulation of microglia function by neural stem cells
title_full Regulation of microglia function by neural stem cells
title_fullStr Regulation of microglia function by neural stem cells
title_full_unstemmed Regulation of microglia function by neural stem cells
title_short Regulation of microglia function by neural stem cells
title_sort regulation of microglia function by neural stem cells
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014810/
https://www.ncbi.nlm.nih.gov/pubmed/36937181
http://dx.doi.org/10.3389/fncel.2023.1130205
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