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Resting-state abnormalities in functional connectivity of the default mode network in migraine: A meta-analysis

Migraine—a disabling neurological disorder, imposes a tremendous burden on societies. To reduce the economic and health toll of the disease, insight into its pathophysiological mechanism is key to improving treatment and prevention. Resting-state functional magnetic resonance imaging (rs-fMRI) studi...

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Autores principales: Hu, Su, Hao, Zeqi, Li, Mengting, Zhao, Mengqi, Wen, Jianjie, Gao, Yanyan, Wang, Qing, Xi, Hongyu, Antwi, Collins Opoku, Jia, Xize, Ren, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014826/
https://www.ncbi.nlm.nih.gov/pubmed/36937687
http://dx.doi.org/10.3389/fnins.2023.1136790
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author Hu, Su
Hao, Zeqi
Li, Mengting
Zhao, Mengqi
Wen, Jianjie
Gao, Yanyan
Wang, Qing
Xi, Hongyu
Antwi, Collins Opoku
Jia, Xize
Ren, Jun
author_facet Hu, Su
Hao, Zeqi
Li, Mengting
Zhao, Mengqi
Wen, Jianjie
Gao, Yanyan
Wang, Qing
Xi, Hongyu
Antwi, Collins Opoku
Jia, Xize
Ren, Jun
author_sort Hu, Su
collection PubMed
description Migraine—a disabling neurological disorder, imposes a tremendous burden on societies. To reduce the economic and health toll of the disease, insight into its pathophysiological mechanism is key to improving treatment and prevention. Resting-state functional magnetic resonance imaging (rs-fMRI) studies suggest abnormal functional connectivity (FC) within the default mode network (DMN) in migraine patients. This implies that DMN connectivity change may represent a biomarker for migraine. However, the FC abnormalities appear inconsistent which hinders our understanding of the potential neuropathology. Therefore, we performed a meta-analysis of the FC within the DMN in migraine patients in the resting state to identify the common FC abnormalities. With efficient search and selection strategies, nine studies (published before July, 2022) were retrieved, containing 204 migraine patients and 199 healthy subjects. We meta-analyzed the data using the Anisotropic Effect Size version of Signed Differential Mapping (AES-SDM) method. Compared with healthy subjects, migraine patients showed increased connectivity in the right calcarine gyrus, left inferior occipital gyrus, left postcentral gyrus, right cerebellum, right parahippocampal gyrus, and right posterior cingulate gyrus, while decreased connectivity in the right postcentral gyrus, left superior frontal gyrus, right superior occipital gyrus, right orbital inferior frontal gyrus, left middle occipital gyrus, left middle frontal gyrus and left inferior frontal gyrus. These results provide a new perspective for the study of the pathophysiology of migraine and facilitate a more targeted treatment of migraine in the future.
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spelling pubmed-100148262023-03-16 Resting-state abnormalities in functional connectivity of the default mode network in migraine: A meta-analysis Hu, Su Hao, Zeqi Li, Mengting Zhao, Mengqi Wen, Jianjie Gao, Yanyan Wang, Qing Xi, Hongyu Antwi, Collins Opoku Jia, Xize Ren, Jun Front Neurosci Neuroscience Migraine—a disabling neurological disorder, imposes a tremendous burden on societies. To reduce the economic and health toll of the disease, insight into its pathophysiological mechanism is key to improving treatment and prevention. Resting-state functional magnetic resonance imaging (rs-fMRI) studies suggest abnormal functional connectivity (FC) within the default mode network (DMN) in migraine patients. This implies that DMN connectivity change may represent a biomarker for migraine. However, the FC abnormalities appear inconsistent which hinders our understanding of the potential neuropathology. Therefore, we performed a meta-analysis of the FC within the DMN in migraine patients in the resting state to identify the common FC abnormalities. With efficient search and selection strategies, nine studies (published before July, 2022) were retrieved, containing 204 migraine patients and 199 healthy subjects. We meta-analyzed the data using the Anisotropic Effect Size version of Signed Differential Mapping (AES-SDM) method. Compared with healthy subjects, migraine patients showed increased connectivity in the right calcarine gyrus, left inferior occipital gyrus, left postcentral gyrus, right cerebellum, right parahippocampal gyrus, and right posterior cingulate gyrus, while decreased connectivity in the right postcentral gyrus, left superior frontal gyrus, right superior occipital gyrus, right orbital inferior frontal gyrus, left middle occipital gyrus, left middle frontal gyrus and left inferior frontal gyrus. These results provide a new perspective for the study of the pathophysiology of migraine and facilitate a more targeted treatment of migraine in the future. Frontiers Media S.A. 2023-03-01 /pmc/articles/PMC10014826/ /pubmed/36937687 http://dx.doi.org/10.3389/fnins.2023.1136790 Text en Copyright © 2023 Hu, Hao, Li, Zhao, Wen, Gao, Wang, Xi, Antwi, Jia and Ren. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Hu, Su
Hao, Zeqi
Li, Mengting
Zhao, Mengqi
Wen, Jianjie
Gao, Yanyan
Wang, Qing
Xi, Hongyu
Antwi, Collins Opoku
Jia, Xize
Ren, Jun
Resting-state abnormalities in functional connectivity of the default mode network in migraine: A meta-analysis
title Resting-state abnormalities in functional connectivity of the default mode network in migraine: A meta-analysis
title_full Resting-state abnormalities in functional connectivity of the default mode network in migraine: A meta-analysis
title_fullStr Resting-state abnormalities in functional connectivity of the default mode network in migraine: A meta-analysis
title_full_unstemmed Resting-state abnormalities in functional connectivity of the default mode network in migraine: A meta-analysis
title_short Resting-state abnormalities in functional connectivity of the default mode network in migraine: A meta-analysis
title_sort resting-state abnormalities in functional connectivity of the default mode network in migraine: a meta-analysis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014826/
https://www.ncbi.nlm.nih.gov/pubmed/36937687
http://dx.doi.org/10.3389/fnins.2023.1136790
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