A mutation in the ZNF687 gene that is responsible for the severe form of Paget’s disease of bone causes severely altered bone remodeling and promotes hepatocellular carcinoma onset in a knock-in mouse model

Paget’s disease (PDB) is a late-onset bone remodeling disorder with a broad spectrum of symptoms and complications. One of the most aggressive forms is caused by the P937R mutation in the ZNF687 gene. Although the genetic involvement of ZNF687 in PDB has been extensively studied, the molecular mecha...

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Detalles Bibliográficos
Autores principales: Russo, Sharon, Scotto di Carlo, Federica, Maurizi, Antonio, Fortunato, Giorgio, Teti, Anna, Licastro, Danilo, Settembre, Carmine, Mello, Tommaso, Gianfrancesco, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014847/
https://www.ncbi.nlm.nih.gov/pubmed/36918542
http://dx.doi.org/10.1038/s41413-023-00250-3

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