Differential toxicity profile of secreted and processed α-Klotho expression over mineral metabolism and bone microstructure

The aging-protective gene α-Klotho (KL) produces two main transcripts. The full-length mRNA generates a transmembrane protein that after proteolytic ectodomain shedding can be detected in serum as processed Klotho (p-KL), and a shorter transcript which codes for a putatively secreted protein (s-KL)....

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Detalles Bibliográficos
Autores principales: Roig-Soriano, Joan, Sánchez-de-Diego, Cristina, Esandi-Jauregui, Jon, Verdés, Sergi, Abraham, Carmela R., Bosch, Assumpció, Ventura, Francesc, Chillón, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014869/
https://www.ncbi.nlm.nih.gov/pubmed/36918615
http://dx.doi.org/10.1038/s41598-023-31117-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10014869/
https://www.ncbi.nlm.nih.gov/pubmed/36918615
http://dx.doi.org/10.1038/s41598-023-31117-6

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