PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1

Phosphatidylinositol-5-phosphate (PtdIns5P)−4-kinases (PIP4Ks) are stress-regulated phosphoinositide kinases able to phosphorylate PtdIns5P to PtdIns(4,5)P2. In cancer patients their expression is typically associated with bad prognosis. Among the three PIP4K isoforms expressed in mammalian cells, P...

Descripción completa

Detalles Bibliográficos
Autores principales: Poli, Alessandro, Pennacchio, Fabrizio A., Ghisleni, Andrea, di Gennaro, Mariagrazia, Lecacheur, Margaux, Nastały, Paulina, Crestani, Michele, Pramotton, Francesca M., Iannelli, Fabio, Beznusenko, Galina, Mironov, Alexander A., Panzetta, Valeria, Fusco, Sabato, Sheth, Bhavwanti, Poulikakos, Dimos, Ferrari, Aldo, Gauthier, Nils, Netti, Paolo A., Divecha, Nullin, Maiuri, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015053/
https://www.ncbi.nlm.nih.gov/pubmed/36918565
http://dx.doi.org/10.1038/s41467-023-37064-0

Ejemplares similares

Ejemplares similares