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Executioner caspases restrict mitochondrial RNA-driven Type I IFN induction during chemotherapy-induced apoptosis

During apoptosis, mitochondrial outer membrane permeabilization (MOMP) enables certain mitochondrial matrix macromolecules to escape into the cytosol. However, the fate of mitochondrial RNA (mtRNA) during apoptosis is unknown. Here, we demonstrate that MOMP results in the cytoplasmic release of mtRN...

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Detalles Bibliográficos
Autores principales:	Killarney, Shane T., Washart, Rachel, Soderquist, Ryan S., Hoj, Jacob P., Lebhar, Jamie, Lin, Kevin H., Wood, Kris C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015073/ https://www.ncbi.nlm.nih.gov/pubmed/36918588 http://dx.doi.org/10.1038/s41467-023-37146-z

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