Characterization of human anti-EpCAM antibodies for developing an antibody–drug conjugate

We previously generated fully human antibody-producing TC-mAb mice for obtaining potential therapeutic monoclonal antibodies (mAbs). In this study, we investigated 377 clones of fully human mAbs against a tumor antigen, epithelial cell adhesion molecule (EpCAM), to determine their antigen binding pr...

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Detalles Bibliográficos
Autores principales: Satofuka, Hiroyuki, Wang, Yayan, Yamazaki, Kyotaro, Hamamichi, Shusei, Fukuhara, Takeshi, Rafique, Abdur, Osako, Nana, Kanazawa, Iori, Endo, Takeshi, Miyake, Naomi, Honma, Kazuhisa, Nagashima, Yuichi, Hichiwa, Genki, Shimoya, Kazuto, Abe, Satoshi, Moriwaki, Takashi, Murakami, Yasufumi, Gao, Xu, Kugoh, Hiroyuki, Oshimura, Mitsuo, Ito, Yuji, Kazuki, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015092/
https://www.ncbi.nlm.nih.gov/pubmed/36918661
http://dx.doi.org/10.1038/s41598-023-31263-x

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