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Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice

Metabolic associated fatty liver disease (MAFLD) encompasses a broad spectrum of hepatic disorders, including steatosis, nonalcoholic steatohepatitis (NASH) and fibrosis. We demonstrated that phosphoenolpyruvate carboxykinase 1 (PCK1) plays a central role in MAFLD progression. Male mice with liver P...

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Detalles Bibliográficos
Autores principales:	Ye, Qian, Liu, Yi, Zhang, Guiji, Deng, Haijun, Wang, Xiaojun, Tuo, Lin, Chen, Chang, Pan, Xuanming, Wu, Kang, Fan, Jiangao, Pan, Qin, Wang, Kai, Huang, Ailong, Tang, Ni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015095/ https://www.ncbi.nlm.nih.gov/pubmed/36918564 http://dx.doi.org/10.1038/s41467-023-37142-3

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