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Combined Heterozygous Genetic Variations in Complement C2 and C8B: An Explanation for Multidimensional Immune Imbalance?

The complement system plays a crucial role in host defense, homeostasis, and tissue regeneration and bridges the innate and the adaptive immune systems. Although the genetic variants in complement C2 (c.839_849+17del; p.(Met280Asnfs*5)) and C8B (c.1625C>T; p.(Thr542Ile)) are known individually, h...

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Detalles Bibliográficos
Autores principales:	Mannes, Marco, Halbgebauer, Rebecca, Wohlgemuth, Lisa, Christian Messerer, David Alexander, Savukoski, Susa, Schultze, Anke, Berger, Bettina, Knapp, Christiane Leonie, Schmidt, Christoph Q., Fürst, Daniel, Hillmer, Morten, Siebert, Reiner, Eriksson, Oskar, Persson, Barbro, Nilsson, Bo, Ekdahl, Kristina Nilsson, Huber-Lang, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	S. Karger AG 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015110/ https://www.ncbi.nlm.nih.gov/pubmed/36858027 http://dx.doi.org/10.1159/000528607

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