A novel chemical attack on Notch-mediated transcription by targeting the NACK ATPase

Notch activation complex kinase (NACK) is a component of the Notch transcriptional machinery critical for the Notch-mediated tumorigenesis. However, the mechanism through which NACK regulates Notch-mediated transcription is not well understood. Here, we demonstrate that NACK binds and hydrolyzes ATP...

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Detalles Bibliográficos
Autores principales: Diluvio, Giulia, Kelley, Tanya T., Lahiry, Mohini, Alvarez-Trotta, Annamil, Kolb, Ellen M., Shersher, Elena, Astudillo, Luisana, Kovall, Rhett A., Schürer, Stephan C., Capobianco, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015116/
https://www.ncbi.nlm.nih.gov/pubmed/36938545
http://dx.doi.org/10.1016/j.omto.2023.02.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015116/
https://www.ncbi.nlm.nih.gov/pubmed/36938545
http://dx.doi.org/10.1016/j.omto.2023.02.008

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