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Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine

Persistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for these patients is needed. Here, we report a cohort of 23 PA cases carrying viral RNA for up to 191 days. PA cases displayed low...

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Autores principales: Qiu, Shaofu, Chen, Zhao, Zhu, Airu, Zeng, Qiuhui, Liu, Hongbo, Liu, Xiaoqing, Ye, Feng, Jin, Yingkang, Wu, Jie, Yang, Chaojie, Wang, Qi, Chen, Fangli, Chen, Lan, Tian, Sai, Du, Xinying, Hu, Qingtao, Cheng, Jinling, Chen, Canjie, Li, Fang, Sun, Jing, Wang, Yanqun, Zhao, Jingxian, Zhao, Jincun, Song, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015148/
https://www.ncbi.nlm.nih.gov/pubmed/36922500
http://dx.doi.org/10.1038/s41392-023-01345-3
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author Qiu, Shaofu
Chen, Zhao
Zhu, Airu
Zeng, Qiuhui
Liu, Hongbo
Liu, Xiaoqing
Ye, Feng
Jin, Yingkang
Wu, Jie
Yang, Chaojie
Wang, Qi
Chen, Fangli
Chen, Lan
Tian, Sai
Du, Xinying
Hu, Qingtao
Cheng, Jinling
Chen, Canjie
Li, Fang
Sun, Jing
Wang, Yanqun
Zhao, Jingxian
Zhao, Jincun
Song, Hongbin
author_facet Qiu, Shaofu
Chen, Zhao
Zhu, Airu
Zeng, Qiuhui
Liu, Hongbo
Liu, Xiaoqing
Ye, Feng
Jin, Yingkang
Wu, Jie
Yang, Chaojie
Wang, Qi
Chen, Fangli
Chen, Lan
Tian, Sai
Du, Xinying
Hu, Qingtao
Cheng, Jinling
Chen, Canjie
Li, Fang
Sun, Jing
Wang, Yanqun
Zhao, Jingxian
Zhao, Jincun
Song, Hongbin
author_sort Qiu, Shaofu
collection PubMed
description Persistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for these patients is needed. Here, we report a cohort of 23 PA cases carrying viral RNA for up to 191 days. PA cases displayed low levels of inflammatory and interferon response, weak antibody response, diminished circulating follicular helper T cells (cTfh), and inadequate specific CD4(+) and CD8(+) T-cell responses during infection, which is distinct from symptomatic infections and resembling impaired immune activation. Administration of a single dose of Ad5-nCoV vaccine to 10 of these PA cases elicited rapid and robust antibody responses as well as coordinated B-cell and cTfh responses, resulting in successful viral clearance. Vaccine-induced antibodies were able to neutralize various variants of concern and persisted for over 6 months, indicating long-term protection. Therefore, our study provides an insight into the immune status of PA infections and highlights vaccination as a potential treatment for prolonged SARS-CoV-2 infections.
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spelling pubmed-100151482023-03-15 Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine Qiu, Shaofu Chen, Zhao Zhu, Airu Zeng, Qiuhui Liu, Hongbo Liu, Xiaoqing Ye, Feng Jin, Yingkang Wu, Jie Yang, Chaojie Wang, Qi Chen, Fangli Chen, Lan Tian, Sai Du, Xinying Hu, Qingtao Cheng, Jinling Chen, Canjie Li, Fang Sun, Jing Wang, Yanqun Zhao, Jingxian Zhao, Jincun Song, Hongbin Signal Transduct Target Ther Article Persistent asymptomatic (PA) SARS-CoV-2 infections have been identified. The immune responses in these patients are unclear, and the development of effective treatments for these patients is needed. Here, we report a cohort of 23 PA cases carrying viral RNA for up to 191 days. PA cases displayed low levels of inflammatory and interferon response, weak antibody response, diminished circulating follicular helper T cells (cTfh), and inadequate specific CD4(+) and CD8(+) T-cell responses during infection, which is distinct from symptomatic infections and resembling impaired immune activation. Administration of a single dose of Ad5-nCoV vaccine to 10 of these PA cases elicited rapid and robust antibody responses as well as coordinated B-cell and cTfh responses, resulting in successful viral clearance. Vaccine-induced antibodies were able to neutralize various variants of concern and persisted for over 6 months, indicating long-term protection. Therefore, our study provides an insight into the immune status of PA infections and highlights vaccination as a potential treatment for prolonged SARS-CoV-2 infections. Nature Publishing Group UK 2023-03-15 /pmc/articles/PMC10015148/ /pubmed/36922500 http://dx.doi.org/10.1038/s41392-023-01345-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Qiu, Shaofu
Chen, Zhao
Zhu, Airu
Zeng, Qiuhui
Liu, Hongbo
Liu, Xiaoqing
Ye, Feng
Jin, Yingkang
Wu, Jie
Yang, Chaojie
Wang, Qi
Chen, Fangli
Chen, Lan
Tian, Sai
Du, Xinying
Hu, Qingtao
Cheng, Jinling
Chen, Canjie
Li, Fang
Sun, Jing
Wang, Yanqun
Zhao, Jingxian
Zhao, Jincun
Song, Hongbin
Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine
title Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine
title_full Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine
title_fullStr Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine
title_full_unstemmed Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine
title_short Successful clearance of persistent SARS-CoV-2 asymptomatic infection following a single dose of Ad5-nCoV vaccine
title_sort successful clearance of persistent sars-cov-2 asymptomatic infection following a single dose of ad5-ncov vaccine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015148/
https://www.ncbi.nlm.nih.gov/pubmed/36922500
http://dx.doi.org/10.1038/s41392-023-01345-3
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