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Maternal opioid treatment after delivery and risk of adverse infant outcomes: population based cohort study
OBJECTIVE: To examine whether maternal opioid treatment after delivery is associated with an increased risk of adverse infant outcomes. DESIGN: Population based cohort study. SETTING: Ontario, Canada. PARTICIPANTS: 865 691 mother-infant pairs discharged from hospital alive within seven days of deliv...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group Ltd.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015218/ https://www.ncbi.nlm.nih.gov/pubmed/36921977 http://dx.doi.org/10.1136/bmj-2022-074005 |
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author | Zipursky, Jonathan S Gomes, Tara Everett, Karl Calzavara, Andrew Paterson, J Michael Austin, Peter C Mamdani, Muhammad M Ray, Joel G Juurlink, David N |
author_facet | Zipursky, Jonathan S Gomes, Tara Everett, Karl Calzavara, Andrew Paterson, J Michael Austin, Peter C Mamdani, Muhammad M Ray, Joel G Juurlink, David N |
author_sort | Zipursky, Jonathan S |
collection | PubMed |
description | OBJECTIVE: To examine whether maternal opioid treatment after delivery is associated with an increased risk of adverse infant outcomes. DESIGN: Population based cohort study. SETTING: Ontario, Canada. PARTICIPANTS: 865 691 mother-infant pairs discharged from hospital alive within seven days of delivery from 1 September 2012 to 31 March 2020. Each mother who filled an opioid prescription within seven days of discharge was propensity score matched to a mother who did not. MAIN OUTCOME MEASURES: The primary outcome was hospital readmission of infants for any reason within 30 days of their mother filling an opioid prescription (index date). Infant related secondary outcomes were any emergency department visit, hospital admission for all cause injury, admission to a neonatal intensive care unit, admission with resuscitation or assisted ventilation, and all cause death. RESULTS: 85 675 mothers (99.8% of the 85 852 mothers prescribed an opioid) who filled an opioid prescription within seven days of discharge after delivery were propensity score matched to 85 675 mothers who did not. Of the infants admitted to hospital within 30 days, 2962 (3.5%) were born to mothers who filled an opioid prescription compared with 3038 (3.5%) born to mothers who did not. Infants of mothers who were prescribed an opioid were no more likely to be admitted to hospital for any reason than infants of mothers who were not prescribed an opioid (hazard ratio 0.98, 95% confidence interval 0.93 to 1.03) and marginally more likely to be taken to an emergency department in the subsequent 30 days (1.04, 1.01 to 1.08), but no differences were found for any other adverse infant outcomes and there were no infant deaths. CONCLUSIONS: Findings from this study suggest no association between maternal opioid prescription after delivery and adverse infant outcomes, including death. |
format | Online Article Text |
id | pubmed-10015218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100152182023-03-16 Maternal opioid treatment after delivery and risk of adverse infant outcomes: population based cohort study Zipursky, Jonathan S Gomes, Tara Everett, Karl Calzavara, Andrew Paterson, J Michael Austin, Peter C Mamdani, Muhammad M Ray, Joel G Juurlink, David N BMJ Research OBJECTIVE: To examine whether maternal opioid treatment after delivery is associated with an increased risk of adverse infant outcomes. DESIGN: Population based cohort study. SETTING: Ontario, Canada. PARTICIPANTS: 865 691 mother-infant pairs discharged from hospital alive within seven days of delivery from 1 September 2012 to 31 March 2020. Each mother who filled an opioid prescription within seven days of discharge was propensity score matched to a mother who did not. MAIN OUTCOME MEASURES: The primary outcome was hospital readmission of infants for any reason within 30 days of their mother filling an opioid prescription (index date). Infant related secondary outcomes were any emergency department visit, hospital admission for all cause injury, admission to a neonatal intensive care unit, admission with resuscitation or assisted ventilation, and all cause death. RESULTS: 85 675 mothers (99.8% of the 85 852 mothers prescribed an opioid) who filled an opioid prescription within seven days of discharge after delivery were propensity score matched to 85 675 mothers who did not. Of the infants admitted to hospital within 30 days, 2962 (3.5%) were born to mothers who filled an opioid prescription compared with 3038 (3.5%) born to mothers who did not. Infants of mothers who were prescribed an opioid were no more likely to be admitted to hospital for any reason than infants of mothers who were not prescribed an opioid (hazard ratio 0.98, 95% confidence interval 0.93 to 1.03) and marginally more likely to be taken to an emergency department in the subsequent 30 days (1.04, 1.01 to 1.08), but no differences were found for any other adverse infant outcomes and there were no infant deaths. CONCLUSIONS: Findings from this study suggest no association between maternal opioid prescription after delivery and adverse infant outcomes, including death. BMJ Publishing Group Ltd. 2023-03-15 /pmc/articles/PMC10015218/ /pubmed/36921977 http://dx.doi.org/10.1136/bmj-2022-074005 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Research Zipursky, Jonathan S Gomes, Tara Everett, Karl Calzavara, Andrew Paterson, J Michael Austin, Peter C Mamdani, Muhammad M Ray, Joel G Juurlink, David N Maternal opioid treatment after delivery and risk of adverse infant outcomes: population based cohort study |
title | Maternal opioid treatment after delivery and risk of adverse infant outcomes: population based cohort study |
title_full | Maternal opioid treatment after delivery and risk of adverse infant outcomes: population based cohort study |
title_fullStr | Maternal opioid treatment after delivery and risk of adverse infant outcomes: population based cohort study |
title_full_unstemmed | Maternal opioid treatment after delivery and risk of adverse infant outcomes: population based cohort study |
title_short | Maternal opioid treatment after delivery and risk of adverse infant outcomes: population based cohort study |
title_sort | maternal opioid treatment after delivery and risk of adverse infant outcomes: population based cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015218/ https://www.ncbi.nlm.nih.gov/pubmed/36921977 http://dx.doi.org/10.1136/bmj-2022-074005 |
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