DNA‐PKcs and ATM modulate mitochondrial ADP‐ATP exchange as an oxidative stress checkpoint mechanism

DNA‐PKcs is a key regulator of DNA double‐strand break repair. Apart from its canonical role in the DNA damage response, DNA‐PKcs is involved in the cellular response to oxidative stress (OS), but its exact role remains unclear. Here, we report that DNA‐PKcs‐deficient human cells display depolarized...

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Detalles Bibliográficos
Autores principales: Chen, Wei‐Min, Chiang, Jui‐Chung, Shang, Zengfu, Palchik, Guillermo, Newman, Ciara, Zhang, Yuanyuan, Davis, Anthony J, Lee, Hsinyu, Chen, Benjamin PC
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015379/
https://www.ncbi.nlm.nih.gov/pubmed/36727301
http://dx.doi.org/10.15252/embj.2022112094

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015379/
https://www.ncbi.nlm.nih.gov/pubmed/36727301
http://dx.doi.org/10.15252/embj.2022112094

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