Cargando…

Post-COVID-19 syndrome: Insights into a novel post-infectious systemic disorder

Coronavirus disease 2019 (COVID-19) is currently considered a complex systemic infectious and inflammatory disease, determined by the infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and the cause of one of the most important epidemiological phenomena in the last century...

Descripción completa

Detalles Bibliográficos
Autores principales: Stoian, Marilena, Procopiescu, Bianca, Șeitan, Silviu, Scarlat, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015558/
https://www.ncbi.nlm.nih.gov/pubmed/36937488
http://dx.doi.org/10.25122/jml-2022-0329
_version_ 1784907229987602432
author Stoian, Marilena
Procopiescu, Bianca
Șeitan, Silviu
Scarlat, Gabriel
author_facet Stoian, Marilena
Procopiescu, Bianca
Șeitan, Silviu
Scarlat, Gabriel
author_sort Stoian, Marilena
collection PubMed
description Coronavirus disease 2019 (COVID-19) is currently considered a complex systemic infectious and inflammatory disease, determined by the infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and the cause of one of the most important epidemiological phenomena in the last century – the COVID-19 pandemic. This infectious-inflammatory disease may generate a wide range of clinical manifestations and biological modifications, explained by the ubiquitous nature of the SARS-CoV-2 receptors, represented by the angiotensin-converting enzyme-2 (ACE-2), and by the host’s violent immune and proinflammatory reaction to the viral infection. These manifestations include immunological disturbances, which, according to certain clinical findings, may persist post-infection, in the form of a presumed systemic inflammatory entity, defined by several clinical concepts with a common pathological significance: post-COVID-19 multisystem (or systemic) inflammatory syndrome, post-COVID syndrome or long-COVID. Although the pathophysiological mechanisms of the post-COVID-19 syndrome are elusive at the present moment, there are currently several studies that describe a systemic inflammatory or autoimmune phenomenon following the remission of the COVID-19 infection in some patients, which suggests the existence of molecular and cellular immune abnormalities, most probably due to the host’s initial violent immune response to the viral infection, in the form of three overlapping entities: secondary hemophagocytic lymph histiocytosis (HLH), macrophage activation syndrome (MAS) and cytokine release syndrome (CRS). Thus, this is reminiscent of different classic autoimmune diseases, in which various infections are risk factors in developing the autoimmune process.
format Online
Article
Text
id pubmed-10015558
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Carol Davila University Press
record_format MEDLINE/PubMed
spelling pubmed-100155582023-03-16 Post-COVID-19 syndrome: Insights into a novel post-infectious systemic disorder Stoian, Marilena Procopiescu, Bianca Șeitan, Silviu Scarlat, Gabriel J Med Life Review Coronavirus disease 2019 (COVID-19) is currently considered a complex systemic infectious and inflammatory disease, determined by the infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and the cause of one of the most important epidemiological phenomena in the last century – the COVID-19 pandemic. This infectious-inflammatory disease may generate a wide range of clinical manifestations and biological modifications, explained by the ubiquitous nature of the SARS-CoV-2 receptors, represented by the angiotensin-converting enzyme-2 (ACE-2), and by the host’s violent immune and proinflammatory reaction to the viral infection. These manifestations include immunological disturbances, which, according to certain clinical findings, may persist post-infection, in the form of a presumed systemic inflammatory entity, defined by several clinical concepts with a common pathological significance: post-COVID-19 multisystem (or systemic) inflammatory syndrome, post-COVID syndrome or long-COVID. Although the pathophysiological mechanisms of the post-COVID-19 syndrome are elusive at the present moment, there are currently several studies that describe a systemic inflammatory or autoimmune phenomenon following the remission of the COVID-19 infection in some patients, which suggests the existence of molecular and cellular immune abnormalities, most probably due to the host’s initial violent immune response to the viral infection, in the form of three overlapping entities: secondary hemophagocytic lymph histiocytosis (HLH), macrophage activation syndrome (MAS) and cytokine release syndrome (CRS). Thus, this is reminiscent of different classic autoimmune diseases, in which various infections are risk factors in developing the autoimmune process. Carol Davila University Press 2023-02 /pmc/articles/PMC10015558/ /pubmed/36937488 http://dx.doi.org/10.25122/jml-2022-0329 Text en ©2023 JOURNAL of MEDICINE and LIFE https://creativecommons.org/licenses/by/3.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Review
Stoian, Marilena
Procopiescu, Bianca
Șeitan, Silviu
Scarlat, Gabriel
Post-COVID-19 syndrome: Insights into a novel post-infectious systemic disorder
title Post-COVID-19 syndrome: Insights into a novel post-infectious systemic disorder
title_full Post-COVID-19 syndrome: Insights into a novel post-infectious systemic disorder
title_fullStr Post-COVID-19 syndrome: Insights into a novel post-infectious systemic disorder
title_full_unstemmed Post-COVID-19 syndrome: Insights into a novel post-infectious systemic disorder
title_short Post-COVID-19 syndrome: Insights into a novel post-infectious systemic disorder
title_sort post-covid-19 syndrome: insights into a novel post-infectious systemic disorder
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015558/
https://www.ncbi.nlm.nih.gov/pubmed/36937488
http://dx.doi.org/10.25122/jml-2022-0329
work_keys_str_mv AT stoianmarilena postcovid19syndromeinsightsintoanovelpostinfectioussystemicdisorder
AT procopiescubianca postcovid19syndromeinsightsintoanovelpostinfectioussystemicdisorder
AT seitansilviu postcovid19syndromeinsightsintoanovelpostinfectioussystemicdisorder
AT scarlatgabriel postcovid19syndromeinsightsintoanovelpostinfectioussystemicdisorder