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Tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs

Cognitive disorders are mental health disorders that can affect cognitive ability. Surgery and anesthesia have been proposed to increase the incidence of cognitive dysfunction, including declines in memory, learning, attention and executive function. Tau protein is a microtubule-associated protein l...

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Autores principales: Chen, Zheping, Wang, Shenghan, Meng, Zhaoqian, Ye, Yuyang, Shan, Guoliang, Wang, Xinyue, Zhao, Xin, Jin, Yanwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015606/
https://www.ncbi.nlm.nih.gov/pubmed/36937655
http://dx.doi.org/10.3389/fnins.2023.1145318
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author Chen, Zheping
Wang, Shenghan
Meng, Zhaoqian
Ye, Yuyang
Shan, Guoliang
Wang, Xinyue
Zhao, Xin
Jin, Yanwu
author_facet Chen, Zheping
Wang, Shenghan
Meng, Zhaoqian
Ye, Yuyang
Shan, Guoliang
Wang, Xinyue
Zhao, Xin
Jin, Yanwu
author_sort Chen, Zheping
collection PubMed
description Cognitive disorders are mental health disorders that can affect cognitive ability. Surgery and anesthesia have been proposed to increase the incidence of cognitive dysfunction, including declines in memory, learning, attention and executive function. Tau protein is a microtubule-associated protein located in the axons of neurons and is important for microtubule assembly and stability; its biological function is mainly regulated by phosphorylation. Phosphorylated tau protein has been associated with cognitive dysfunction mediated by disrupting the stability of the microtubule structure. There is an increasing consensus that anesthetic drugs can cause cognitive impairment. Herein, we reviewed the latest literature and compared the relationship between tau protein and cognitive impairment caused by different anesthetics. Our results substantiated that tau protein phosphorylation is essential in cognitive dysfunction caused by anesthetic drugs, and the possible mechanism can be summarized as “anesthetic drugs-kinase/phosphatase-p-Tau-cognitive impairment”.
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spelling pubmed-100156062023-03-16 Tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs Chen, Zheping Wang, Shenghan Meng, Zhaoqian Ye, Yuyang Shan, Guoliang Wang, Xinyue Zhao, Xin Jin, Yanwu Front Neurosci Neuroscience Cognitive disorders are mental health disorders that can affect cognitive ability. Surgery and anesthesia have been proposed to increase the incidence of cognitive dysfunction, including declines in memory, learning, attention and executive function. Tau protein is a microtubule-associated protein located in the axons of neurons and is important for microtubule assembly and stability; its biological function is mainly regulated by phosphorylation. Phosphorylated tau protein has been associated with cognitive dysfunction mediated by disrupting the stability of the microtubule structure. There is an increasing consensus that anesthetic drugs can cause cognitive impairment. Herein, we reviewed the latest literature and compared the relationship between tau protein and cognitive impairment caused by different anesthetics. Our results substantiated that tau protein phosphorylation is essential in cognitive dysfunction caused by anesthetic drugs, and the possible mechanism can be summarized as “anesthetic drugs-kinase/phosphatase-p-Tau-cognitive impairment”. Frontiers Media S.A. 2023-03-01 /pmc/articles/PMC10015606/ /pubmed/36937655 http://dx.doi.org/10.3389/fnins.2023.1145318 Text en Copyright © 2023 Chen, Wang, Meng, Ye, Shan, Wang, Zhao and Jin. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Chen, Zheping
Wang, Shenghan
Meng, Zhaoqian
Ye, Yuyang
Shan, Guoliang
Wang, Xinyue
Zhao, Xin
Jin, Yanwu
Tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs
title Tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs
title_full Tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs
title_fullStr Tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs
title_full_unstemmed Tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs
title_short Tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs
title_sort tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015606/
https://www.ncbi.nlm.nih.gov/pubmed/36937655
http://dx.doi.org/10.3389/fnins.2023.1145318
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