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AMH producing purely cystic virilizing adult granulosa cell tumor in 17 years old girl: a case report and review of literatures
BACKGROUND: Androgen-producing granulosa cell tumor in adolescent girl is rare condition and clinical characteristics are not fully elucidated. CASE PRESENTATION: Seventeen years old girl complained of secondary amenorrhea was referred to our out-patient consultation. Markedly elevated serum testost...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015727/ https://www.ncbi.nlm.nih.gov/pubmed/36922845 http://dx.doi.org/10.1186/s13048-023-01134-0 |
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author | Kitajima, Michio Kajimura, Itsuki Kitajima, Yuriko Murakami, Naoko Matsumura, Asako Matsumoto, Kanako Harada, Ayumi Hasegawa, Yuri Miura, Kiyonori |
author_facet | Kitajima, Michio Kajimura, Itsuki Kitajima, Yuriko Murakami, Naoko Matsumura, Asako Matsumoto, Kanako Harada, Ayumi Hasegawa, Yuri Miura, Kiyonori |
author_sort | Kitajima, Michio |
collection | PubMed |
description | BACKGROUND: Androgen-producing granulosa cell tumor in adolescent girl is rare condition and clinical characteristics are not fully elucidated. CASE PRESENTATION: Seventeen years old girl complained of secondary amenorrhea was referred to our out-patient consultation. Markedly elevated serum testosterone, LH, and AMH levels were noted. Mild hirsutism and clitoromegaly were presented. Transabdominal ultrasonography and MRI revealed cystic mass occupied pelvic cavity probably originated from left ovary. Right ovary showed polycystic appearance. Laparoscopic left ovarian cystectomy was performed. After the surgery, her menstruation resumed along with normalized hormonal parameters, and clinical hyperandrogenism were improved. Since the scarcity of cellular lining of inner cyst wall, definitive pathological diagnosis was difficult. After the consultation with gynecological pathologist, the tumor was diagnosed as sex cord stromal tumor, highly suspicious for adult granulosa cell tumor. Residual left salpingo-oophorectomy was performed by additional laparoscopic surgery. Her serum testosterone and AMH levels were remained low with regular menstrual cycles and no evidence of recurrence. CONCLUSIONS: Androgen-producing cystic granulosa cell tumor is rare gynecological disorders, which need both gynecologic oncological and endocrinological approach. Its clinical manifestations may bring some clues to the pathogenesis of ovulatory dysfunctions, such as polycystic ovary syndrome. |
format | Online Article Text |
id | pubmed-10015727 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-100157272023-03-16 AMH producing purely cystic virilizing adult granulosa cell tumor in 17 years old girl: a case report and review of literatures Kitajima, Michio Kajimura, Itsuki Kitajima, Yuriko Murakami, Naoko Matsumura, Asako Matsumoto, Kanako Harada, Ayumi Hasegawa, Yuri Miura, Kiyonori J Ovarian Res Case Report BACKGROUND: Androgen-producing granulosa cell tumor in adolescent girl is rare condition and clinical characteristics are not fully elucidated. CASE PRESENTATION: Seventeen years old girl complained of secondary amenorrhea was referred to our out-patient consultation. Markedly elevated serum testosterone, LH, and AMH levels were noted. Mild hirsutism and clitoromegaly were presented. Transabdominal ultrasonography and MRI revealed cystic mass occupied pelvic cavity probably originated from left ovary. Right ovary showed polycystic appearance. Laparoscopic left ovarian cystectomy was performed. After the surgery, her menstruation resumed along with normalized hormonal parameters, and clinical hyperandrogenism were improved. Since the scarcity of cellular lining of inner cyst wall, definitive pathological diagnosis was difficult. After the consultation with gynecological pathologist, the tumor was diagnosed as sex cord stromal tumor, highly suspicious for adult granulosa cell tumor. Residual left salpingo-oophorectomy was performed by additional laparoscopic surgery. Her serum testosterone and AMH levels were remained low with regular menstrual cycles and no evidence of recurrence. CONCLUSIONS: Androgen-producing cystic granulosa cell tumor is rare gynecological disorders, which need both gynecologic oncological and endocrinological approach. Its clinical manifestations may bring some clues to the pathogenesis of ovulatory dysfunctions, such as polycystic ovary syndrome. BioMed Central 2023-03-15 /pmc/articles/PMC10015727/ /pubmed/36922845 http://dx.doi.org/10.1186/s13048-023-01134-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Kitajima, Michio Kajimura, Itsuki Kitajima, Yuriko Murakami, Naoko Matsumura, Asako Matsumoto, Kanako Harada, Ayumi Hasegawa, Yuri Miura, Kiyonori AMH producing purely cystic virilizing adult granulosa cell tumor in 17 years old girl: a case report and review of literatures |
title | AMH producing purely cystic virilizing adult granulosa cell tumor in 17 years old girl: a case report and review of literatures |
title_full | AMH producing purely cystic virilizing adult granulosa cell tumor in 17 years old girl: a case report and review of literatures |
title_fullStr | AMH producing purely cystic virilizing adult granulosa cell tumor in 17 years old girl: a case report and review of literatures |
title_full_unstemmed | AMH producing purely cystic virilizing adult granulosa cell tumor in 17 years old girl: a case report and review of literatures |
title_short | AMH producing purely cystic virilizing adult granulosa cell tumor in 17 years old girl: a case report and review of literatures |
title_sort | amh producing purely cystic virilizing adult granulosa cell tumor in 17 years old girl: a case report and review of literatures |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015727/ https://www.ncbi.nlm.nih.gov/pubmed/36922845 http://dx.doi.org/10.1186/s13048-023-01134-0 |
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