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4-Octyl itaconate attenuates glycemic deterioration by regulating macrophage polarization in mouse models of type 1 diabetes

BACKGROUND: Pancreatic beta cell dysfunction and activated macrophage infiltration are early features in type 1 diabetes pathogenesis. A tricarboxylic acid cycle metabolite that can strongly activate NF-E2-related factor 2 (Nrf2) in macrophages, itaconate is important in a series of inflammatory-ass...

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Detalles Bibliográficos
Autores principales:	He, Sunyue, Zhao, Yuchen, Wang, Guoxing, Ke, Qiaofang, Wu, Nan, Lu, Lusi, Wu, Jiahua, Sun, Shuiya, Jin, Weihua, Zhang, Wenjing, Zhou, Jiaqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015936/ https://www.ncbi.nlm.nih.gov/pubmed/36918798 http://dx.doi.org/10.1186/s10020-023-00626-5

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