Excellent Repigmentation of Generalized Vitiligo with Oral Baricitinib Combined with NB-UVB Phototherapy

Vitiligo is an acquired autoimmune skin disorder, clinically characterized by distinct white macules and patches resulting from progressive melanocyte destruction. JAK-STAT pathway plays an important role in the loss of epidermal melanocytes. Baricitinib can block the JAK-STAT pathway and the downst...

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Detalles Bibliográficos
Autores principales: Li, Xinxin, Sun, Yifang, Du, Juan, Wang, Fang, Ding, Xiaolan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015970/
https://www.ncbi.nlm.nih.gov/pubmed/36936753
http://dx.doi.org/10.2147/CCID.S396430
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author Li, Xinxin
Sun, Yifang
Du, Juan
Wang, Fang
Ding, Xiaolan
author_facet Li, Xinxin
Sun, Yifang
Du, Juan
Wang, Fang
Ding, Xiaolan
author_sort Li, Xinxin
collection PubMed
description Vitiligo is an acquired autoimmune skin disorder, clinically characterized by distinct white macules and patches resulting from progressive melanocyte destruction. JAK-STAT pathway plays an important role in the loss of epidermal melanocytes. Baricitinib can block the JAK-STAT pathway and the downstream chemokines as a new JAK1/2 inhibitor. In this report, we describe the successful treatment of 2 patients with oral baricitinib combined with NB-UVB phototherapy, which provides a good alternative and supplementary to treat refractory vitiligo.
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spelling pubmed-100159702023-03-16 Excellent Repigmentation of Generalized Vitiligo with Oral Baricitinib Combined with NB-UVB Phototherapy Li, Xinxin Sun, Yifang Du, Juan Wang, Fang Ding, Xiaolan Clin Cosmet Investig Dermatol Case Series Vitiligo is an acquired autoimmune skin disorder, clinically characterized by distinct white macules and patches resulting from progressive melanocyte destruction. JAK-STAT pathway plays an important role in the loss of epidermal melanocytes. Baricitinib can block the JAK-STAT pathway and the downstream chemokines as a new JAK1/2 inhibitor. In this report, we describe the successful treatment of 2 patients with oral baricitinib combined with NB-UVB phototherapy, which provides a good alternative and supplementary to treat refractory vitiligo. Dove 2023-03-11 /pmc/articles/PMC10015970/ /pubmed/36936753 http://dx.doi.org/10.2147/CCID.S396430 Text en © 2023 Li et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Series
Li, Xinxin
Sun, Yifang
Du, Juan
Wang, Fang
Ding, Xiaolan
Excellent Repigmentation of Generalized Vitiligo with Oral Baricitinib Combined with NB-UVB Phototherapy
title Excellent Repigmentation of Generalized Vitiligo with Oral Baricitinib Combined with NB-UVB Phototherapy
title_full Excellent Repigmentation of Generalized Vitiligo with Oral Baricitinib Combined with NB-UVB Phototherapy
title_fullStr Excellent Repigmentation of Generalized Vitiligo with Oral Baricitinib Combined with NB-UVB Phototherapy
title_full_unstemmed Excellent Repigmentation of Generalized Vitiligo with Oral Baricitinib Combined with NB-UVB Phototherapy
title_short Excellent Repigmentation of Generalized Vitiligo with Oral Baricitinib Combined with NB-UVB Phototherapy
title_sort excellent repigmentation of generalized vitiligo with oral baricitinib combined with nb-uvb phototherapy
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10015970/
https://www.ncbi.nlm.nih.gov/pubmed/36936753
http://dx.doi.org/10.2147/CCID.S396430
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