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What do Cochrane systematic reviews say about probiotics as preventive interventions?

BACKGROUND: Probiotics have been used for a range of clinical situations and their use is strongly encouraged by the media worldwide. This study identified and summarized all Cochrane systematic reviews about the preventive effects of probiotics in clinical practice. DESIGN AND SETTING: Review of sy...

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Autores principales: Braga, Vinícius Lopes, Rocha, Luana Pompeu dos Santos, Bernardo, Daniel Damasceno, Cruz, Carolina de Oliveira, Riera, Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Paulista de Medicina - APM 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016009/
https://www.ncbi.nlm.nih.gov/pubmed/29267517
http://dx.doi.org/10.1590/1516-3180.2017.0310241017
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author Braga, Vinícius Lopes
Rocha, Luana Pompeu dos Santos
Bernardo, Daniel Damasceno
Cruz, Carolina de Oliveira
Riera, Rachel
author_facet Braga, Vinícius Lopes
Rocha, Luana Pompeu dos Santos
Bernardo, Daniel Damasceno
Cruz, Carolina de Oliveira
Riera, Rachel
author_sort Braga, Vinícius Lopes
collection PubMed
description BACKGROUND: Probiotics have been used for a range of clinical situations and their use is strongly encouraged by the media worldwide. This study identified and summarized all Cochrane systematic reviews about the preventive effects of probiotics in clinical practice. DESIGN AND SETTING: Review of systematic reviews, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp). METHODS: We included all Cochrane reviews on any probiotics when they were used as preventive interventions and compared with no intervention, placebo or any other pharmacological or non-pharmacological intervention. RESULTS: 17 Cochrane systematic reviews fulfilled our inclusion criteria and were summarized in this report. None of the reviews included in the present study provided high-quality evidence for any outcome. The benefits from use of probiotics included decreased incidence of antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea; decreased incidence of upper respiratory tract infections and duration of episodes; decreased need for antibiotics and absences from school due to colds; and decreased incidence of ventilator-associated pneumonia. Probiotics seem to decrease the incidence of gestational diabetes mellitus, birthweight, risk of vaginal infection and incidence of eczema. CONCLUSION: Despite the marketing and the benefits associated with probiotics, there is little scientific evidence supporting the use of probiotics. None of the reviews provided any high-quality evidence for prevention of illnesses through use of probiotics. More trials are needed to gain better knowledge of probiotics and to confirm when their use is beneficial and cost-effective.
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spelling pubmed-100160092023-03-16 What do Cochrane systematic reviews say about probiotics as preventive interventions? Braga, Vinícius Lopes Rocha, Luana Pompeu dos Santos Bernardo, Daniel Damasceno Cruz, Carolina de Oliveira Riera, Rachel Sao Paulo Med J Cochrane Highlight BACKGROUND: Probiotics have been used for a range of clinical situations and their use is strongly encouraged by the media worldwide. This study identified and summarized all Cochrane systematic reviews about the preventive effects of probiotics in clinical practice. DESIGN AND SETTING: Review of systematic reviews, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (Unifesp). METHODS: We included all Cochrane reviews on any probiotics when they were used as preventive interventions and compared with no intervention, placebo or any other pharmacological or non-pharmacological intervention. RESULTS: 17 Cochrane systematic reviews fulfilled our inclusion criteria and were summarized in this report. None of the reviews included in the present study provided high-quality evidence for any outcome. The benefits from use of probiotics included decreased incidence of antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea; decreased incidence of upper respiratory tract infections and duration of episodes; decreased need for antibiotics and absences from school due to colds; and decreased incidence of ventilator-associated pneumonia. Probiotics seem to decrease the incidence of gestational diabetes mellitus, birthweight, risk of vaginal infection and incidence of eczema. CONCLUSION: Despite the marketing and the benefits associated with probiotics, there is little scientific evidence supporting the use of probiotics. None of the reviews provided any high-quality evidence for prevention of illnesses through use of probiotics. More trials are needed to gain better knowledge of probiotics and to confirm when their use is beneficial and cost-effective. Associação Paulista de Medicina - APM 2017-09-28 /pmc/articles/PMC10016009/ /pubmed/29267517 http://dx.doi.org/10.1590/1516-3180.2017.0310241017 Text en © 2022 by Associação Paulista de Medicina https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons license.
spellingShingle Cochrane Highlight
Braga, Vinícius Lopes
Rocha, Luana Pompeu dos Santos
Bernardo, Daniel Damasceno
Cruz, Carolina de Oliveira
Riera, Rachel
What do Cochrane systematic reviews say about probiotics as preventive interventions?
title What do Cochrane systematic reviews say about probiotics as preventive interventions?
title_full What do Cochrane systematic reviews say about probiotics as preventive interventions?
title_fullStr What do Cochrane systematic reviews say about probiotics as preventive interventions?
title_full_unstemmed What do Cochrane systematic reviews say about probiotics as preventive interventions?
title_short What do Cochrane systematic reviews say about probiotics as preventive interventions?
title_sort what do cochrane systematic reviews say about probiotics as preventive interventions?
topic Cochrane Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016009/
https://www.ncbi.nlm.nih.gov/pubmed/29267517
http://dx.doi.org/10.1590/1516-3180.2017.0310241017
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