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Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells

The incretin receptors, glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR), are prime therapeutic targets for the treatment of type 2 diabetes (T2D) and obesity. They are expressed in pancreatic beta cells where they potentiate insulin release...

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Detalles Bibliográficos
Autores principales:	Manchanda, Yusman, Bitsi, Stavroula, Chen, Shiqian, Broichhagen, Johannes, Bernardino de la Serna, Jorge, Jones, Ben, Tomas, Alejandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016038/ https://www.ncbi.nlm.nih.gov/pubmed/36774542 http://dx.doi.org/10.1210/endocr/bqad028

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