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Depressive Features in Individuals with First Episode Psychosis: Psychopathological and Treatment Considerations from A 2-Year Follow-Up Study
OBJECTIVE: Comorbid depression is quite common in early psychosis and specifically related to suicidal behavior and poor long-term outcomes. However, Depressive Symptoms (DS) are often neglected in both research and treatment, especially at the psychosis onset. The goals of this investigation were:...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Giovanni Fioriti Editore srl
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016103/ https://www.ncbi.nlm.nih.gov/pubmed/36936626 http://dx.doi.org/10.36131/cnfioritieditore20230105 |
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author | Pelizza, Lorenzo Leuci, Emanuela Quattrone, Emanuela Azzali, Silvia Paulillo, Giuseppina Pupo, Simona Pellegrini, Pietro |
author_facet | Pelizza, Lorenzo Leuci, Emanuela Quattrone, Emanuela Azzali, Silvia Paulillo, Giuseppina Pupo, Simona Pellegrini, Pietro |
author_sort | Pelizza, Lorenzo |
collection | PubMed |
description | OBJECTIVE: Comorbid depression is quite common in early psychosis and specifically related to suicidal behavior and poor long-term outcomes. However, Depressive Symptoms (DS) are often neglected in both research and treatment, especially at the psychosis onset. The goals of this investigation were: (a) to longitudinally explore DS levels in patients with First Episode Psychosis (FEP) during 24 months of follow-up, and (b) to investigate the associations of DS with psychopathology and intervention components of an “Early Intervention in Psychosis” (EIP) program across the follow-up period. METHOD: The Global Assessment of Functioning (GAF) and the Positive And Negative Syndrome Scale (PANSS) were completed by 266 FEP subjects. A linear regression analysis with DS as the dependent parameter and psychopathological and treatment characteristics as independent variables was performed (both at baseline and across the follow-up period). RESULTS: DS had enduring associations with PANSS “Positive Symptoms” and “Negative Symptoms” subscores. During the investigation, FEP subjects significantly improved their DS severity levels. This was related to the number of individual psychotherapy meetings supplied within the EIP protocol, as well as to a higher antidepressant dose and a lower antipsychotic dose prescribed during the follow-up. CONCLUSIONS: DS are quite prominent in FEP, even at the recruitment time in EIP services. Nevertheless, DS severity tends to diminish overtime, especially with the provision of specialized EIP treatments. |
format | Online Article Text |
id | pubmed-10016103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Giovanni Fioriti Editore srl |
record_format | MEDLINE/PubMed |
spelling | pubmed-100161032023-03-16 Depressive Features in Individuals with First Episode Psychosis: Psychopathological and Treatment Considerations from A 2-Year Follow-Up Study Pelizza, Lorenzo Leuci, Emanuela Quattrone, Emanuela Azzali, Silvia Paulillo, Giuseppina Pupo, Simona Pellegrini, Pietro Clin Neuropsychiatry Research Paper OBJECTIVE: Comorbid depression is quite common in early psychosis and specifically related to suicidal behavior and poor long-term outcomes. However, Depressive Symptoms (DS) are often neglected in both research and treatment, especially at the psychosis onset. The goals of this investigation were: (a) to longitudinally explore DS levels in patients with First Episode Psychosis (FEP) during 24 months of follow-up, and (b) to investigate the associations of DS with psychopathology and intervention components of an “Early Intervention in Psychosis” (EIP) program across the follow-up period. METHOD: The Global Assessment of Functioning (GAF) and the Positive And Negative Syndrome Scale (PANSS) were completed by 266 FEP subjects. A linear regression analysis with DS as the dependent parameter and psychopathological and treatment characteristics as independent variables was performed (both at baseline and across the follow-up period). RESULTS: DS had enduring associations with PANSS “Positive Symptoms” and “Negative Symptoms” subscores. During the investigation, FEP subjects significantly improved their DS severity levels. This was related to the number of individual psychotherapy meetings supplied within the EIP protocol, as well as to a higher antidepressant dose and a lower antipsychotic dose prescribed during the follow-up. CONCLUSIONS: DS are quite prominent in FEP, even at the recruitment time in EIP services. Nevertheless, DS severity tends to diminish overtime, especially with the provision of specialized EIP treatments. Giovanni Fioriti Editore srl 2023-02 /pmc/articles/PMC10016103/ /pubmed/36936626 http://dx.doi.org/10.36131/cnfioritieditore20230105 Text en © 2023 Giovanni Fioriti Editore s.r.l. This is an open access article. Distribution and reproduction are permitted in any medium, provided the original author(s) and source are credited. |
spellingShingle | Research Paper Pelizza, Lorenzo Leuci, Emanuela Quattrone, Emanuela Azzali, Silvia Paulillo, Giuseppina Pupo, Simona Pellegrini, Pietro Depressive Features in Individuals with First Episode Psychosis: Psychopathological and Treatment Considerations from A 2-Year Follow-Up Study |
title | Depressive Features in Individuals with First Episode Psychosis: Psychopathological and Treatment Considerations from A 2-Year Follow-Up Study |
title_full | Depressive Features in Individuals with First Episode Psychosis: Psychopathological and Treatment Considerations from A 2-Year Follow-Up Study |
title_fullStr | Depressive Features in Individuals with First Episode Psychosis: Psychopathological and Treatment Considerations from A 2-Year Follow-Up Study |
title_full_unstemmed | Depressive Features in Individuals with First Episode Psychosis: Psychopathological and Treatment Considerations from A 2-Year Follow-Up Study |
title_short | Depressive Features in Individuals with First Episode Psychosis: Psychopathological and Treatment Considerations from A 2-Year Follow-Up Study |
title_sort | depressive features in individuals with first episode psychosis: psychopathological and treatment considerations from a 2-year follow-up study |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10016103/ https://www.ncbi.nlm.nih.gov/pubmed/36936626 http://dx.doi.org/10.36131/cnfioritieditore20230105 |
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