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Design and Synthesis of Novel HIV-1 NNRTIs with Bicyclic Cores and with Improved Physicochemical Properties

[Image: see text] Non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent cornerstones of current regimens for treatment of human immunodeficiency virus type 1 (HIV-1) infections. However, NNRTIs usually suffer from low aqueous solubility and the emergence of resistant viral strains. In t...

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Detalles Bibliográficos
Autores principales:	Prener, Ladislav, Baszczyňski, Ondřej, Kaiser, Martin M., Dračínský, Martin, Stepan, George, Lee, Yu-Jen, Brumshtein, Boris, Yu, Helen, Jansa, Petr, Lansdon, Eric B., Janeba, Zlatko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017027/ https://www.ncbi.nlm.nih.gov/pubmed/36652602 http://dx.doi.org/10.1021/acs.jmedchem.2c01574

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