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Solanoeclepin B, a hatching factor for potato cyst nematode

The potato cyst nematode (PCN) causes extensive crop losses worldwide. Because the hatching of PCN requires host-derived molecules known as hatching factors (HFs), regulating HF production in host plants may help to control this harmful pest. Solanoeclepin A (SEA), isolated from potato, is the most...

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Autores principales: Shimizu, Kosuke, Akiyama, Ryota, Okamura, Yuya, Ogawa, Chihiro, Masuda, Yuki, Sakata, Itaru, Watanabe, Bunta, Sugimoto, Yukihiro, Kushida, Atsuhiko, Tanino, Keiji, Mizutani, Masaharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017031/
https://www.ncbi.nlm.nih.gov/pubmed/36921046
http://dx.doi.org/10.1126/sciadv.adf4166
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author Shimizu, Kosuke
Akiyama, Ryota
Okamura, Yuya
Ogawa, Chihiro
Masuda, Yuki
Sakata, Itaru
Watanabe, Bunta
Sugimoto, Yukihiro
Kushida, Atsuhiko
Tanino, Keiji
Mizutani, Masaharu
author_facet Shimizu, Kosuke
Akiyama, Ryota
Okamura, Yuya
Ogawa, Chihiro
Masuda, Yuki
Sakata, Itaru
Watanabe, Bunta
Sugimoto, Yukihiro
Kushida, Atsuhiko
Tanino, Keiji
Mizutani, Masaharu
author_sort Shimizu, Kosuke
collection PubMed
description The potato cyst nematode (PCN) causes extensive crop losses worldwide. Because the hatching of PCN requires host-derived molecules known as hatching factors (HFs), regulating HF production in host plants may help to control this harmful pest. Solanoeclepin A (SEA), isolated from potato, is the most active HF for PCN; however, its biosynthesis is completely unknown. We discovered a HF called solanoeclepin B (SEB) from potato and tomato root exudates and showed that SEB was biosynthesized in the plant and converted to SEA outside the plant by biotic agents. Moreover, we identified five SEB biosynthetic genes encoding three 2-oxoglutarate-dependent dioxygenases and two cytochrome P450 monooxygenases in tomato. Exudates from tomato hairy roots in which each of the genes was disrupted contained no SEB and had low hatch-stimulating activity for PCN. These findings will help to breed crops with a lower risk of PCN infection.
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spelling pubmed-100170312023-03-16 Solanoeclepin B, a hatching factor for potato cyst nematode Shimizu, Kosuke Akiyama, Ryota Okamura, Yuya Ogawa, Chihiro Masuda, Yuki Sakata, Itaru Watanabe, Bunta Sugimoto, Yukihiro Kushida, Atsuhiko Tanino, Keiji Mizutani, Masaharu Sci Adv Biomedicine and Life Sciences The potato cyst nematode (PCN) causes extensive crop losses worldwide. Because the hatching of PCN requires host-derived molecules known as hatching factors (HFs), regulating HF production in host plants may help to control this harmful pest. Solanoeclepin A (SEA), isolated from potato, is the most active HF for PCN; however, its biosynthesis is completely unknown. We discovered a HF called solanoeclepin B (SEB) from potato and tomato root exudates and showed that SEB was biosynthesized in the plant and converted to SEA outside the plant by biotic agents. Moreover, we identified five SEB biosynthetic genes encoding three 2-oxoglutarate-dependent dioxygenases and two cytochrome P450 monooxygenases in tomato. Exudates from tomato hairy roots in which each of the genes was disrupted contained no SEB and had low hatch-stimulating activity for PCN. These findings will help to breed crops with a lower risk of PCN infection. American Association for the Advancement of Science 2023-03-15 /pmc/articles/PMC10017031/ /pubmed/36921046 http://dx.doi.org/10.1126/sciadv.adf4166 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Shimizu, Kosuke
Akiyama, Ryota
Okamura, Yuya
Ogawa, Chihiro
Masuda, Yuki
Sakata, Itaru
Watanabe, Bunta
Sugimoto, Yukihiro
Kushida, Atsuhiko
Tanino, Keiji
Mizutani, Masaharu
Solanoeclepin B, a hatching factor for potato cyst nematode
title Solanoeclepin B, a hatching factor for potato cyst nematode
title_full Solanoeclepin B, a hatching factor for potato cyst nematode
title_fullStr Solanoeclepin B, a hatching factor for potato cyst nematode
title_full_unstemmed Solanoeclepin B, a hatching factor for potato cyst nematode
title_short Solanoeclepin B, a hatching factor for potato cyst nematode
title_sort solanoeclepin b, a hatching factor for potato cyst nematode
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017031/
https://www.ncbi.nlm.nih.gov/pubmed/36921046
http://dx.doi.org/10.1126/sciadv.adf4166
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