Synthetic enforcement of STING signaling in cancer cells appropriates the immune microenvironment for checkpoint inhibitor therapy

Immune checkpoint inhibitors (ICIs) enhance anticancer immunity by releasing repressive signals into tumor microenvironments (TMEs). To be effective, ICIs require preexisting immunologically “hot” niches for tumor antigen presentation and lymphocyte recruitment. How the mutational landscape of cance...

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Detalles Bibliográficos
Autores principales: Vornholz, Larsen, Isay, Sophie E., Kurgyis, Zsuzsanna, Strobl, Daniel C., Loll, Patricia, Mosa, Mohammed H., Luecken, Malte D., Sterr, Michael, Lickert, Heiko, Winter, Christof, Greten, Florian R., Farin, Henner F., Theis, Fabian J., Ruland, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017047/
https://www.ncbi.nlm.nih.gov/pubmed/36921054
http://dx.doi.org/10.1126/sciadv.add8564

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