A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance

Mutations of the androgen receptor (AR) associated with prostate cancer and androgen insensitivity syndrome may profoundly influence its structure, protein interaction network, and binding to chromatin, resulting in altered transcription signatures and drug responses. Current structural information...

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Detalles Bibliográficos
Autores principales: Alegre-Martí, Andrea, Jiménez-Panizo, Alba, Martínez-Tébar, Adrián, Poulard, Coralie, Peralta-Moreno, M. Núria, Abella, Montserrat, Antón, Rosa, Chiñas, Marcos, Eckhard, Ulrich, Piulats, Josep M., Rojas, Ana M., Fernández-Recio, Juan, Rubio-Martínez, Jaime, Le Romancer, Muriel, Aytes, Álvaro, Fuentes-Prior, Pablo, Estébanez-Perpiñá, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017050/
https://www.ncbi.nlm.nih.gov/pubmed/36921044
http://dx.doi.org/10.1126/sciadv.ade2175

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