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Cardiac Troponin, Cognitive Function, and Dementia: A Systematic Review

Elevated cardiac troponin, a biomarker of myocardial injury, has been found in individuals with brain damage and lower cognitive function. We conducted a systematic review to examine the association of troponin with cognitive function, incidence of dementia and dementia-related outcomes. PubMed, Web...

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Autores principales: Zonneveld, Michelle H, Abbel, Denise, le Cessie, Saskia, Jukema, J. Wouter, Noordam, Raymond, Trompet, Stella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JKL International LLC 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017151/
https://www.ncbi.nlm.nih.gov/pubmed/37008066
http://dx.doi.org/10.14336/AD.2022.0818
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author Zonneveld, Michelle H
Abbel, Denise
le Cessie, Saskia
Jukema, J. Wouter
Noordam, Raymond
Trompet, Stella
author_facet Zonneveld, Michelle H
Abbel, Denise
le Cessie, Saskia
Jukema, J. Wouter
Noordam, Raymond
Trompet, Stella
author_sort Zonneveld, Michelle H
collection PubMed
description Elevated cardiac troponin, a biomarker of myocardial injury, has been found in individuals with brain damage and lower cognitive function. We conducted a systematic review to examine the association of troponin with cognitive function, incidence of dementia and dementia-related outcomes. PubMed, Web of Science and EMBASE were searched from inception to August 2022. Inclusion criteria were: (i) population-based cohort studies; (ii) troponin measured as determinant; and (iii) cognitive function in any metric or diagnosis of any type of dementia or dementia-related measures as outcomes. Fourteen studies were identified and included, with a combined total of 38,286 participants. Of these studies, four examined dementia-related outcomes, eight studies examined cognitive function, and two studies examined both dementia-related outcomes and cognitive function. Studies report higher troponin to be associated with higher prevalence of cognitive impairment (n=1), incident dementia (n=1), increased risk of dementia hospitalization (specifically due to vascular dementia) (n=1), but not with incident Alzheimer’s Disease (n=2). Majority of studies on cognitive function found elevated troponin also associated with worse global cognitive function (n=3), attention (n=2), reaction time (n=1) and visuomotor speed (n=1), both cross-sectionally and prospectively. Evidence regarding the association between higher troponin and memory, executive function, processing speed, language and visuospatial function was mixed. This was the first systematic review on the association between troponin, cognitive function, and dementia. Higher troponin is associated with subclinical cerebrovascular damage and might act as a risk-marker of cognitive vulnerability.
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spelling pubmed-100171512023-04-01 Cardiac Troponin, Cognitive Function, and Dementia: A Systematic Review Zonneveld, Michelle H Abbel, Denise le Cessie, Saskia Jukema, J. Wouter Noordam, Raymond Trompet, Stella Aging Dis Review Elevated cardiac troponin, a biomarker of myocardial injury, has been found in individuals with brain damage and lower cognitive function. We conducted a systematic review to examine the association of troponin with cognitive function, incidence of dementia and dementia-related outcomes. PubMed, Web of Science and EMBASE were searched from inception to August 2022. Inclusion criteria were: (i) population-based cohort studies; (ii) troponin measured as determinant; and (iii) cognitive function in any metric or diagnosis of any type of dementia or dementia-related measures as outcomes. Fourteen studies were identified and included, with a combined total of 38,286 participants. Of these studies, four examined dementia-related outcomes, eight studies examined cognitive function, and two studies examined both dementia-related outcomes and cognitive function. Studies report higher troponin to be associated with higher prevalence of cognitive impairment (n=1), incident dementia (n=1), increased risk of dementia hospitalization (specifically due to vascular dementia) (n=1), but not with incident Alzheimer’s Disease (n=2). Majority of studies on cognitive function found elevated troponin also associated with worse global cognitive function (n=3), attention (n=2), reaction time (n=1) and visuomotor speed (n=1), both cross-sectionally and prospectively. Evidence regarding the association between higher troponin and memory, executive function, processing speed, language and visuospatial function was mixed. This was the first systematic review on the association between troponin, cognitive function, and dementia. Higher troponin is associated with subclinical cerebrovascular damage and might act as a risk-marker of cognitive vulnerability. JKL International LLC 2023-04-01 /pmc/articles/PMC10017151/ /pubmed/37008066 http://dx.doi.org/10.14336/AD.2022.0818 Text en copyright: © 2022 Zonneveld et al. https://creativecommons.org/licenses/by/2.0/this is an open access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Review
Zonneveld, Michelle H
Abbel, Denise
le Cessie, Saskia
Jukema, J. Wouter
Noordam, Raymond
Trompet, Stella
Cardiac Troponin, Cognitive Function, and Dementia: A Systematic Review
title Cardiac Troponin, Cognitive Function, and Dementia: A Systematic Review
title_full Cardiac Troponin, Cognitive Function, and Dementia: A Systematic Review
title_fullStr Cardiac Troponin, Cognitive Function, and Dementia: A Systematic Review
title_full_unstemmed Cardiac Troponin, Cognitive Function, and Dementia: A Systematic Review
title_short Cardiac Troponin, Cognitive Function, and Dementia: A Systematic Review
title_sort cardiac troponin, cognitive function, and dementia: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017151/
https://www.ncbi.nlm.nih.gov/pubmed/37008066
http://dx.doi.org/10.14336/AD.2022.0818
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