Pulmonary Cryptococcosis Diagnosed by a Transbronchial Lung Cryobiopsy in a Patient with Rheumatoid Arthritis

A 77-year-old woman with seronegative rheumatoid arthritis who was being treated with prednisolone (8 mg/day) and methotrexate (12 mg/week) visited our hospital with an 11-day history of a fever and dyspnea. Chest computed tomography showed infiltration in the right lower lobe. A transbronchial lung...

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Autores principales: Motokura, Yumi, Ito, Akihiro, Yokoe, Shinya, Iri, Osamu, Nishimura, Keisuke, Kamiyama, Shinya, Ishida, Tadashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017238/
https://www.ncbi.nlm.nih.gov/pubmed/35908974
http://dx.doi.org/10.2169/internalmedicine.9764-22
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author Motokura, Yumi
Ito, Akihiro
Yokoe, Shinya
Iri, Osamu
Nishimura, Keisuke
Kamiyama, Shinya
Ishida, Tadashi
author_facet Motokura, Yumi
Ito, Akihiro
Yokoe, Shinya
Iri, Osamu
Nishimura, Keisuke
Kamiyama, Shinya
Ishida, Tadashi
author_sort Motokura, Yumi
collection PubMed
description A 77-year-old woman with seronegative rheumatoid arthritis who was being treated with prednisolone (8 mg/day) and methotrexate (12 mg/week) visited our hospital with an 11-day history of a fever and dyspnea. Chest computed tomography showed infiltration in the right lower lobe. A transbronchial lung cryobiopsy (TBLC) showed cryptococcal cells, and bronchoalveolar lavage fluid later showed growth of Cryptococcus neoformans. She was treated with amphotericin B and flucytosine for about four weeks, and the pulmonary shadows improved. The treatment was then changed to fluconazole as outpatient consolidation and maintenance therapy. A rare case of pulmonary cryptococcosis diagnosed by a TBLC is reported.
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spelling pubmed-100172382023-03-16 Pulmonary Cryptococcosis Diagnosed by a Transbronchial Lung Cryobiopsy in a Patient with Rheumatoid Arthritis Motokura, Yumi Ito, Akihiro Yokoe, Shinya Iri, Osamu Nishimura, Keisuke Kamiyama, Shinya Ishida, Tadashi Intern Med Case Report A 77-year-old woman with seronegative rheumatoid arthritis who was being treated with prednisolone (8 mg/day) and methotrexate (12 mg/week) visited our hospital with an 11-day history of a fever and dyspnea. Chest computed tomography showed infiltration in the right lower lobe. A transbronchial lung cryobiopsy (TBLC) showed cryptococcal cells, and bronchoalveolar lavage fluid later showed growth of Cryptococcus neoformans. She was treated with amphotericin B and flucytosine for about four weeks, and the pulmonary shadows improved. The treatment was then changed to fluconazole as outpatient consolidation and maintenance therapy. A rare case of pulmonary cryptococcosis diagnosed by a TBLC is reported. The Japanese Society of Internal Medicine 2022-07-29 2023-02-15 /pmc/articles/PMC10017238/ /pubmed/35908974 http://dx.doi.org/10.2169/internalmedicine.9764-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Motokura, Yumi
Ito, Akihiro
Yokoe, Shinya
Iri, Osamu
Nishimura, Keisuke
Kamiyama, Shinya
Ishida, Tadashi
Pulmonary Cryptococcosis Diagnosed by a Transbronchial Lung Cryobiopsy in a Patient with Rheumatoid Arthritis
title Pulmonary Cryptococcosis Diagnosed by a Transbronchial Lung Cryobiopsy in a Patient with Rheumatoid Arthritis
title_full Pulmonary Cryptococcosis Diagnosed by a Transbronchial Lung Cryobiopsy in a Patient with Rheumatoid Arthritis
title_fullStr Pulmonary Cryptococcosis Diagnosed by a Transbronchial Lung Cryobiopsy in a Patient with Rheumatoid Arthritis
title_full_unstemmed Pulmonary Cryptococcosis Diagnosed by a Transbronchial Lung Cryobiopsy in a Patient with Rheumatoid Arthritis
title_short Pulmonary Cryptococcosis Diagnosed by a Transbronchial Lung Cryobiopsy in a Patient with Rheumatoid Arthritis
title_sort pulmonary cryptococcosis diagnosed by a transbronchial lung cryobiopsy in a patient with rheumatoid arthritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017238/
https://www.ncbi.nlm.nih.gov/pubmed/35908974
http://dx.doi.org/10.2169/internalmedicine.9764-22
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