A Tumefactive Fibroinflammatory Lesion of the Head and Neck Mimicking Immunoglobulin G4-related Disease

A 67-year-old woman with a 5-year history of recurrent swollen eyelids and epistaxis, diagnosed as immunoglobulin G4-related diseases (IgG4-RD) based on hyper-IgG4-emia and IgG4-positive cell infiltration to the lesion, was referred to our department due to recurrent symptoms despite corticosteroid...

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Detalles Bibliográficos
Autores principales: Nakamura, Koki, Kanda, Masatoshi, Notohara, Kenji, Sugawara, Masanari, Nagahata, Ken, Suzuki, Chisako, Takahashi, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017247/
https://www.ncbi.nlm.nih.gov/pubmed/35908973
http://dx.doi.org/10.2169/internalmedicine.9760-22
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author Nakamura, Koki
Kanda, Masatoshi
Notohara, Kenji
Sugawara, Masanari
Nagahata, Ken
Suzuki, Chisako
Takahashi, Hiroki
author_facet Nakamura, Koki
Kanda, Masatoshi
Notohara, Kenji
Sugawara, Masanari
Nagahata, Ken
Suzuki, Chisako
Takahashi, Hiroki
author_sort Nakamura, Koki
collection PubMed
description A 67-year-old woman with a 5-year history of recurrent swollen eyelids and epistaxis, diagnosed as immunoglobulin G4-related diseases (IgG4-RD) based on hyper-IgG4-emia and IgG4-positive cell infiltration to the lesion, was referred to our department due to recurrent symptoms despite corticosteroid therapies. Computed tomography revealed an osteoclastic sinus mass with prominent neutrophil infiltration and necrosis that was incompatible with IgG4-RD histopathologically. Finally, she was diagnosed with a tumefactive fibroinflammatory lesion (TFIL) of the head and neck and treated with high-dose corticosteroids. Physicians should remember that TFIL can mimic IgG4-RD in the head and neck region with prominent neutrophil infiltration and necrosis.
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spelling pubmed-100172472023-03-16 A Tumefactive Fibroinflammatory Lesion of the Head and Neck Mimicking Immunoglobulin G4-related Disease Nakamura, Koki Kanda, Masatoshi Notohara, Kenji Sugawara, Masanari Nagahata, Ken Suzuki, Chisako Takahashi, Hiroki Intern Med Case Report A 67-year-old woman with a 5-year history of recurrent swollen eyelids and epistaxis, diagnosed as immunoglobulin G4-related diseases (IgG4-RD) based on hyper-IgG4-emia and IgG4-positive cell infiltration to the lesion, was referred to our department due to recurrent symptoms despite corticosteroid therapies. Computed tomography revealed an osteoclastic sinus mass with prominent neutrophil infiltration and necrosis that was incompatible with IgG4-RD histopathologically. Finally, she was diagnosed with a tumefactive fibroinflammatory lesion (TFIL) of the head and neck and treated with high-dose corticosteroids. Physicians should remember that TFIL can mimic IgG4-RD in the head and neck region with prominent neutrophil infiltration and necrosis. The Japanese Society of Internal Medicine 2022-07-29 2023-02-15 /pmc/articles/PMC10017247/ /pubmed/35908973 http://dx.doi.org/10.2169/internalmedicine.9760-22 Text en Copyright © 2023 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nakamura, Koki
Kanda, Masatoshi
Notohara, Kenji
Sugawara, Masanari
Nagahata, Ken
Suzuki, Chisako
Takahashi, Hiroki
A Tumefactive Fibroinflammatory Lesion of the Head and Neck Mimicking Immunoglobulin G4-related Disease
title A Tumefactive Fibroinflammatory Lesion of the Head and Neck Mimicking Immunoglobulin G4-related Disease
title_full A Tumefactive Fibroinflammatory Lesion of the Head and Neck Mimicking Immunoglobulin G4-related Disease
title_fullStr A Tumefactive Fibroinflammatory Lesion of the Head and Neck Mimicking Immunoglobulin G4-related Disease
title_full_unstemmed A Tumefactive Fibroinflammatory Lesion of the Head and Neck Mimicking Immunoglobulin G4-related Disease
title_short A Tumefactive Fibroinflammatory Lesion of the Head and Neck Mimicking Immunoglobulin G4-related Disease
title_sort tumefactive fibroinflammatory lesion of the head and neck mimicking immunoglobulin g4-related disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017247/
https://www.ncbi.nlm.nih.gov/pubmed/35908973
http://dx.doi.org/10.2169/internalmedicine.9760-22
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