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Ion channel chameleons: Switching ion selectivity by alternative splicing

Voltage-gated sodium and calcium channels are distinct, evolutionarily related ion channels that achieve remarkable ion selectivity despite sharing an overall similar structure. Classical studies have shown that ion selectivity is determined by specific binding of ions to the channel pore, enabled b...

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Detalles Bibliográficos
Autores principales: Hsu, Allen L., Ben-Johny, Manu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017353/
https://www.ncbi.nlm.nih.gov/pubmed/36707054
http://dx.doi.org/10.1016/j.jbc.2023.102946