Krüppel-like factor 15 in liver diseases: Insights into metabolic reprogramming

Liver diseases, characterized by metabolic disorder, have become a global public health problem with high morbidity and mortality. Krüppel-like factor 15 (KLF15) is a zinc-finger transcription factor mainly enriched in liver. Increasing evidence suggests that hepatic KLF15 is activated rapidly durin...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Hao, Li, Lan-Lan, Du, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017497/
https://www.ncbi.nlm.nih.gov/pubmed/36937859
http://dx.doi.org/10.3389/fphar.2023.1115226
_version_ 1784907599482716160
author Chen, Hao
Li, Lan-Lan
Du, Yan
author_facet Chen, Hao
Li, Lan-Lan
Du, Yan
author_sort Chen, Hao
collection PubMed
description Liver diseases, characterized by metabolic disorder, have become a global public health problem with high morbidity and mortality. Krüppel-like factor 15 (KLF15) is a zinc-finger transcription factor mainly enriched in liver. Increasing evidence suggests that hepatic KLF15 is activated rapidly during fasting, and contributes to the regulation of gluconeogenesis, lipid, amino acid catabolism, bile acids, endobiotic and xenobiotic metabolism. This review summarizes the latest advances of KLF15 in metabolic reprogramming, and explore the function of KLF15 in acute liver injury, hepatitis B virus, and autoimmune hepatitis. which aims to evaluate the potential of KLF15 as a therapeutic target and prognostic biomarker for liver diseases.
format Online
Article
Text
id pubmed-10017497
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-100174972023-03-17 Krüppel-like factor 15 in liver diseases: Insights into metabolic reprogramming Chen, Hao Li, Lan-Lan Du, Yan Front Pharmacol Pharmacology Liver diseases, characterized by metabolic disorder, have become a global public health problem with high morbidity and mortality. Krüppel-like factor 15 (KLF15) is a zinc-finger transcription factor mainly enriched in liver. Increasing evidence suggests that hepatic KLF15 is activated rapidly during fasting, and contributes to the regulation of gluconeogenesis, lipid, amino acid catabolism, bile acids, endobiotic and xenobiotic metabolism. This review summarizes the latest advances of KLF15 in metabolic reprogramming, and explore the function of KLF15 in acute liver injury, hepatitis B virus, and autoimmune hepatitis. which aims to evaluate the potential of KLF15 as a therapeutic target and prognostic biomarker for liver diseases. Frontiers Media S.A. 2023-03-02 /pmc/articles/PMC10017497/ /pubmed/36937859 http://dx.doi.org/10.3389/fphar.2023.1115226 Text en Copyright © 2023 Chen, Li and Du. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Chen, Hao
Li, Lan-Lan
Du, Yan
Krüppel-like factor 15 in liver diseases: Insights into metabolic reprogramming
title Krüppel-like factor 15 in liver diseases: Insights into metabolic reprogramming
title_full Krüppel-like factor 15 in liver diseases: Insights into metabolic reprogramming
title_fullStr Krüppel-like factor 15 in liver diseases: Insights into metabolic reprogramming
title_full_unstemmed Krüppel-like factor 15 in liver diseases: Insights into metabolic reprogramming
title_short Krüppel-like factor 15 in liver diseases: Insights into metabolic reprogramming
title_sort krüppel-like factor 15 in liver diseases: insights into metabolic reprogramming
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10017497/
https://www.ncbi.nlm.nih.gov/pubmed/36937859
http://dx.doi.org/10.3389/fphar.2023.1115226
work_keys_str_mv AT chenhao kruppellikefactor15inliverdiseasesinsightsintometabolicreprogramming
AT lilanlan kruppellikefactor15inliverdiseasesinsightsintometabolicreprogramming
AT duyan kruppellikefactor15inliverdiseasesinsightsintometabolicreprogramming

Ejemplares similares